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Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in sickle cell disease: A phase 2, open-label study.
van Dijk MJ, Rab MAE, van Oirschot BA, Bos J, Derichs C, Rijneveld AW, Cnossen MH, Nur E, Biemond BJ, Bartels M, Jans JJM, van Solinge WW, Schutgens REG, van Wijk R, van Beers EJ. van Dijk MJ, et al. Among authors: rab mae. Am J Hematol. 2022 Jul;97(7):E226-E229. doi: 10.1002/ajh.26554. Epub 2022 Apr 16. Am J Hematol. 2022. PMID: 35384026 Free article. Clinical Trial. No abstract available.
Rapid and reproducible characterization of sickling during automated deoxygenation in sickle cell disease patients.
Rab MAE, van Oirschot BA, Bos J, Merkx TH, van Wesel ACW, Abdulmalik O, Safo MK, Versluijs BA, Houwing ME, Cnossen MH, Riedl J, Schutgens REG, Pasterkamp G, Bartels M, van Beers EJ, van Wijk R. Rab MAE, et al. Am J Hematol. 2019 May;94(5):575-584. doi: 10.1002/ajh.25443. Epub 2019 Mar 8. Am J Hematol. 2019. PMID: 30784099 Free PMC article.
Density, heterogeneity and deformability of red cells as markers of clinical severity in hereditary spherocytosis.
Huisjes R, Makhro A, Llaudet-Planas E, Hertz L, Petkova-Kirova P, Verhagen LP, Pignatelli S, Rab MAE, Schiffelers RM, Seiler E, van Solinge WW, Corrons JV, Kaestner L, Mañú-Pereira M, Bogdanova A, van Wijk R. Huisjes R, et al. Among authors: rab mae. Haematologica. 2020 Jan 31;105(2):338-347. doi: 10.3324/haematol.2018.188151. Print 2020. Haematologica. 2020. PMID: 31147440 Free PMC article.
AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes.
Rab MAE, Van Oirschot BA, Kosinski PA, Hixon J, Johnson K, Chubukov V, Dang L, Pasterkamp G, Van Straaten S, Van Solinge WW, Van Beers EJ, Kung C, Van Wijk R. Rab MAE, et al. Haematologica. 2021 Jan 1;106(1):238-249. doi: 10.3324/haematol.2019.238865. Haematologica. 2021. PMID: 31974203 Free PMC article.
Oxygen gradient ektacytometry-derived biomarkers are associated with vaso-occlusive crises and correlate with treatment response in sickle cell disease.
Rab MAE, Kanne CK, Bos J, van Oirschot BA, Boisson C, Houwing ME, Gerritsma J, Teske E, Renoux C, Riedl J, Schutgens REG, Bartels M, Nur E, Joly P, Fort R, Cnossen MH, van Wijk R, Connes P, van Beers EJ, Sheehan VA. Rab MAE, et al. Am J Hematol. 2021 Jan;96(1):E29-E32. doi: 10.1002/ajh.26031. Epub 2020 Nov 11. Am J Hematol. 2021. PMID: 33095451 Free PMC article. No abstract available.
32 results