Safety and efficacy of mitapivat, an oral pyruvate kinase activator, in sickle cell disease: A phase 2, open-label study

Affiliations

• ¹ Center for Benign Hematology, Thrombosis and Hemostasis - Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
• ² Department of Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
• ³ Department of Hematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
• ⁴ Department of Hematology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
• ⁵ Department of Pediatric Hematology, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
• ⁶ Department of Hematology, Amsterdam University Medical Center, Amsterdam, The Netherlands.
• ⁷ Department of Blood Cell Research, Sanquin Research, Amsterdam, The Netherlands.
• ⁸ Section Metabolic Diagnostics, Department of Genetics, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.