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Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.
Martín-Pardillos A, Tsaalbi-Shtylik A, Chen S, Lazare S, van Os RP, Dethmers-Ausema A, Fakouri NB, Bosshard M, Aprigliano R, van Loon B, Salvatori DCF, Hashimoto K, Dingemanse-van der Spek C, Moriya M, Rasmussen LJ, de Haan G, Raaijmakers MHGP, de Wind N. Martín-Pardillos A, et al. Among authors: raaijmakers mhgp. Blood. 2017 Sep 28;130(13):1523-1534. doi: 10.1182/blood-2017-01-764274. Epub 2017 Aug 21. Blood. 2017. PMID: 28827409 Free PMC article.
Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.
Zambetti NA, Ping Z, Chen S, Kenswil KJG, Mylona MA, Sanders MA, Hoogenboezem RM, Bindels EMJ, Adisty MN, Van Strien PMH, van der Leije CS, Westers TM, Cremers EMP, Milanese C, Mastroberardino PG, van Leeuwen JPTM, van der Eerden BCJ, Touw IP, Kuijpers TW, Kanaar R, van de Loosdrecht AA, Vogl T, Raaijmakers MHGP. Zambetti NA, et al. Among authors: raaijmakers mhgp. Cell Stem Cell. 2016 Nov 3;19(5):613-627. doi: 10.1016/j.stem.2016.08.021. Epub 2016 Sep 22. Cell Stem Cell. 2016. PMID: 27666011 Free article.
The mesenchymal niche in MDS.
Pronk E, Raaijmakers MHGP. Pronk E, et al. Among authors: raaijmakers mhgp. Blood. 2019 Mar 7;133(10):1031-1038. doi: 10.1182/blood-2018-10-844639. Epub 2019 Jan 22. Blood. 2019. PMID: 30670448 Free article. Review.
RUNX1 germline variants in RUNX1-mutant AML: how frequent?
Ernst MPT, Kavelaars FG, Löwenberg B, Valk PJM, Raaijmakers MHGP. Ernst MPT, et al. Among authors: raaijmakers mhgp. Blood. 2021 Mar 11;137(10):1428-1431. doi: 10.1182/blood.2020008478. Blood. 2021. PMID: 33075818 Free article. No abstract available.
Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes.
Zambetti NA, Bindels EM, Van Strien PM, Valkhof MG, Adisty MN, Hoogenboezem RM, Sanders MA, Rommens JM, Touw IP, Raaijmakers MH. Zambetti NA, et al. Haematologica. 2015 Oct;100(10):1285-93. doi: 10.3324/haematol.2015.131573. Epub 2015 Jul 16. Haematologica. 2015. PMID: 26185170 Free PMC article.
Activation of NF-κB driven inflammatory programs in mesenchymal elements attenuates hematopoiesis in low-risk myelodysplastic syndromes.
Ping Z, Chen S, Hermans SJF, Kenswil KJG, Feyen J, van Dijk C, Bindels EMJ, Mylona AM, Adisty NM, Hoogenboezem RM, Sanders MA, Cremers EMP, Lindenbergh-Kortleve DJ, Samsom JN, van de Loosdrecht AA, Raaijmakers MHGP. Ping Z, et al. Among authors: raaijmakers mhgp. Leukemia. 2019 Feb;33(2):536-541. doi: 10.1038/s41375-018-0267-x. Epub 2018 Oct 12. Leukemia. 2019. PMID: 30315231 Free PMC article.
Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome.
Ribezzo F, Snoeren IAM, Ziegler S, Stoelben J, Olofsen PA, Henic A, Ferreira MV, Chen S, Stalmann USA, Buesche G, Hoogenboezem RM, Kramann R, Platzbecker U, Raaijmakers MHGP, Ebert BL, Schneider RK. Ribezzo F, et al. Among authors: raaijmakers mhgp. Leukemia. 2019 Jul;33(7):1759-1772. doi: 10.1038/s41375-018-0350-3. Epub 2019 Jan 16. Leukemia. 2019. PMID: 30651631
46 results