Aging of the Hematopoietic Stem Cell Niche: An Unnerving Matter

Marc H G P Raaijmakers

doi:10.1016/j.stem.2019.08.008

Aging of the Hematopoietic Stem Cell Niche: An Unnerving Matter

Cell Stem Cell. 2019 Sep 5;25(3):301-303. doi: 10.1016/j.stem.2019.08.008.

Author

Marc H G P Raaijmakers¹

Affiliation

¹ Erasmus Medical Center Cancer Institute, Department of Hematology, Faculty Building Rm Ee-1393. dr. Molewaterplein 50, 3015GE Rotterdam, the Netherlands. Electronic address: m.h.g.raaijmakers@erasmusmc.nl.

PMID: 31491392
DOI: 10.1016/j.stem.2019.08.008

Abstract

The drivers of aging in the hematopoietic system remain incompletely understood. In this issue of Cell Stem Cell, Ho et al. (2019) report that functional switching of β-adrenergic nerve signaling underlies remodeling of stem cell niches, driving age-associated alterations in hematopoiesis.

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MeSH terms

Bone Marrow*
Hematopoiesis
Hematopoietic Stem Cells
Myeloid Cells
Stem Cell Niche*