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NGLY1 mutations cause protein aggregation in human neurons.
Manole A, Wong T, Rhee A, Novak S, Chin SM, Tsimring K, Paucar A, Williams A, Newmeyer TF, Schafer ST, Rosh I, Kaushik S, Hoffman R, Chen S, Wang G, Snyder M, Cuervo AM, Andrade L, Manor U, Lee K, Jones JR, Stern S, Marchetto MC, Gage FH. Manole A, et al. Cell Rep. 2023 Dec 26;42(12):113466. doi: 10.1016/j.celrep.2023.113466. Epub 2023 Nov 30. Cell Rep. 2023. PMID: 38039131 Free PMC article.
An in vivo neuroimmune organoid model to study human microglia phenotypes.
Schafer ST, Mansour AA, Schlachetzki JCM, Pena M, Ghassemzadeh S, Mitchell L, Mar A, Quang D, Stumpf S, Ortiz IS, Lana AJ, Baek C, Zaghal R, Glass CK, Nimmerjahn A, Gage FH. Schafer ST, et al. Cell. 2023 May 11;186(10):2111-2126.e20. doi: 10.1016/j.cell.2023.04.022. Cell. 2023. PMID: 37172564
Novel therapeutic approaches to target neurodegeneration.
de la Fuente AG, Pelucchi S, Mertens J, Di Luca M, Mauceri D, Marcello E. de la Fuente AG, et al. Br J Pharmacol. 2023 Jul;180(13):1651-1673. doi: 10.1111/bph.16078. Epub 2023 Apr 26. Br J Pharmacol. 2023. PMID: 36965025 Free PMC article. Review.
Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease.
Traxler L, Herdy JR, Stefanoni D, Eichhorner S, Pelucchi S, Szücs A, Santagostino A, Kim Y, Agarwal RK, Schlachetzki JCM, Glass CK, Lagerwall J, Galasko D, Gage FH, D'Alessandro A, Mertens J. Traxler L, et al. Cell Metab. 2022 Sep 6;34(9):1248-1263.e6. doi: 10.1016/j.cmet.2022.07.014. Epub 2022 Aug 19. Cell Metab. 2022. PMID: 35987203 Free PMC article.