R01 GM102498/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

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Subject: R01 GM102498/GM/NIGMS NIH HHS/United States[Grant - PubMed

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Year	Number of Results
2011	1
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2016	2
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Cellular and molecular mechanisms of Hedgehog signalling.

Zhang Y, Beachy PA. Zhang Y, et al. Nat Rev Mol Cell Biol. 2023 Sep;24(9):668-687. doi: 10.1038/s41580-023-00591-1. Epub 2023 Mar 17. Nat Rev Mol Cell Biol. 2023. PMID: 36932157 Review.

Dispatched uses Na⁺ flux to power release of lipid-modified Hedgehog.

Wang Q, Asarnow DE, Ding K, Mann RK, Hatakeyama J, Zhang Y, Ma Y, Cheng Y, Beachy PA. Wang Q, et al. Nature. 2021 Nov;599(7884):320-324. doi: 10.1038/s41586-021-03996-0. Epub 2021 Oct 27. Nature. 2021. PMID: 34707294 Free PMC article.

Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.

Zhang Y, Lu WJ, Bulkley DP, Liang J, Ralko A, Han S, Roberts KJ, Li A, Cho W, Cheng Y, Manglik A, Beachy PA. Zhang Y, et al. Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28838-28846. doi: 10.1073/pnas.2011560117. Epub 2020 Nov 2. Proc Natl Acad Sci U S A. 2020. PMID: 33139559 Free PMC article.

Smoothened stimulation by membrane sterols drives Hedgehog pathway activity.

Deshpande I, Liang J, Hedeen D, Roberts KJ, Zhang Y, Ha B, Latorraca NR, Faust B, Dror RO, Beachy PA, Myers BR, Manglik A. Deshpande I, et al. Nature. 2019 Jul;571(7764):284-288. doi: 10.1038/s41586-019-1355-4. Epub 2019 Jul 1. Nature. 2019. PMID: 31263273 Free PMC article.

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.

Zhang Y, Bulkley DP, Xin Y, Roberts KJ, Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y, Beachy PA. Zhang Y, et al. Cell. 2018 Nov 15;175(5):1352-1364.e14. doi: 10.1016/j.cell.2018.10.026. Epub 2018 Nov 8. Cell. 2018. PMID: 30415841 Free PMC article.

Cilia-Associated Oxysterols Activate Smoothened.

Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF. Raleigh DR, et al. Mol Cell. 2018 Oct 18;72(2):316-327.e5. doi: 10.1016/j.molcel.2018.08.034. Mol Cell. 2018. PMID: 30340023 Free PMC article.

Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium.

Myers BR, Neahring L, Zhang Y, Roberts KJ, Beachy PA. Myers BR, et al. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11141-E11150. doi: 10.1073/pnas.1717891115. Epub 2017 Dec 11. Proc Natl Acad Sci U S A. 2017. PMID: 29229834 Free PMC article.

Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols.

Sever N, Mann RK, Xu L, Snell WJ, Hernandez-Lara CI, Porter NA, Beachy PA. Sever N, et al. Proc Natl Acad Sci U S A. 2016 May 24;113(21):5904-9. doi: 10.1073/pnas.1604984113. Epub 2016 May 9. Proc Natl Acad Sci U S A. 2016. PMID: 27162362 Free PMC article.

Effects of Combined Treatment With Arsenic Trioxide and Itraconazole in Patients With Refractory Metastatic Basal Cell Carcinoma.

Ally MS, Ransohoff K, Sarin K, Atwood SX, Rezaee M, Bailey-Healy I, Kim J, Beachy PA, Chang AL, Oro A, Tang JY, Colevas AD. Ally MS, et al. JAMA Dermatol. 2016 Apr;152(4):452-6. doi: 10.1001/jamadermatol.2015.5473. JAMA Dermatol. 2016. PMID: 26765315 Free PMC article.

A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.

Oh S, Kato M, Zhang C, Guo Y, Beachy PA. Oh S, et al. PLoS One. 2015 Aug 13;10(8):e0135804. doi: 10.1371/journal.pone.0135804. eCollection 2015. PLoS One. 2015. PMID: 26271100 Free PMC article.

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