R01 DK111427/DK/NIDDK NIH HHS/United States[Grants and Funding] - Search Results

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Subject: R01 DK111427/DK/NIDDK NIH HHS/United States[Grant - PubMed

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Year	Number of Results
2018	3
2019	9
2020	4
2021	3
2023	1
2024	0

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Scribble scrambles parathyroid hormone receptor interactions to regulate phosphate and vitamin D homeostasis.

Stewart BZ, Mamonova T, Sneddon WB, Javorsky A, Yang Y, Wang B, Nolin TD, Humbert PO, Friedman PA, Kvansakul M. Stewart BZ, et al. Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2220851120. doi: 10.1073/pnas.2220851120. Epub 2023 May 30. Proc Natl Acad Sci U S A. 2023. PMID: 37252981 Free PMC article.

Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation.

White AD, Peña KA, Clark LJ, Maria CS, Liu S, Jean-Alphonse FG, Lee JY, Lei S, Cheng Z, Tu CL, Fang F, Szeto N, Gardella TJ, Xiao K, Gellman SH, Bahar I, Sutkeviciute I, Chang W, Vilardaga JP. White AD, et al. Sci Signal. 2021 Oct 5;14(703):eabc5944. doi: 10.1126/scisignal.abc5944. Epub 2021 Oct 5. Sci Signal. 2021. PMID: 34609896 Free PMC article.

Shining light on location-biased cAMP signaling.

Vilardaga JP, Sutkeviciute I, Peña KA. Vilardaga JP, et al. J Biol Chem. 2021 Sep;297(3):101118. doi: 10.1016/j.jbc.2021.101118. Epub 2021 Aug 23. J Biol Chem. 2021. PMID: 34437901 Free PMC article.

Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport.

Vistrup-Parry M, Sneddon WB, Bach S, Strømgaard K, Friedman PA, Mamonova T. Vistrup-Parry M, et al. J Biol Chem. 2021 Jan-Jun;296:100473. doi: 10.1016/j.jbc.2021.100473. Epub 2021 Feb 24. J Biol Chem. 2021. PMID: 33639163 Free PMC article.

PTH hypersecretion triggered by a GABA_B1 and Ca²⁺-sensing receptor heterocomplex in hyperparathyroidism.

Chang W, Tu CL, Jean-Alphonse FG, Herberger A, Cheng Z, Hwong J, Ho H, Li A, Wang D, Liu H, White AD, Suh I, Shen W, Duh QY, Khanafshar E, Shoback DM, Xiao K, Vilardaga JP. Chang W, et al. Nat Metab. 2020 Mar;2(3):243-255. doi: 10.1038/s42255-020-0175-z. Epub 2020 Mar 9. Nat Metab. 2020. PMID: 32694772 Free PMC article.

Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation.

Clark LJ, Krieger J, White AD, Bondarenko V, Lei S, Fang F, Lee JY, Doruker P, Böttke T, Jean-Alphonse F, Tang P, Gardella TJ, Xiao K, Sutkeviciute I, Coin I, Bahar I, Vilardaga JP. Clark LJ, et al. Nat Chem Biol. 2020 Oct;16(10):1096-1104. doi: 10.1038/s41589-020-0567-0. Epub 2020 Jul 6. Nat Chem Biol. 2020. PMID: 32632293 Free PMC article.

Structural insights into emergent signaling modes of G protein-coupled receptors.

Sutkeviciute I, Vilardaga JP. Sutkeviciute I, et al. J Biol Chem. 2020 Aug 14;295(33):11626-11642. doi: 10.1074/jbc.REV120.009348. Epub 2020 Jun 22. J Biol Chem. 2020. PMID: 32571882 Free PMC article. Review.

G_q/11-dependent regulation of endosomal cAMP generation by parathyroid hormone class B GPCR.

White AD, Jean-Alphonse FG, Fang F, Peña KA, Liu S, König GM, Inoue A, Aslanoglou D, Gellman SH, Kostenis E, Xiao K, Vilardaga JP. White AD, et al. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7455-7460. doi: 10.1073/pnas.1918158117. Epub 2020 Mar 17. Proc Natl Acad Sci U S A. 2020. PMID: 32184323 Free PMC article.

PTH/PTHrP Receptor Signaling, Allostery, and Structures.

Sutkeviciute I, Clark LJ, White AD, Gardella TJ, Vilardaga JP. Sutkeviciute I, et al. Trends Endocrinol Metab. 2019 Nov;30(11):860-874. doi: 10.1016/j.tem.2019.07.011. Trends Endocrinol Metab. 2019. PMID: 31699241 Free PMC article. Review.

Use of Backbone Modification To Enlarge the Spatiotemporal Diversity of Parathyroid Hormone Receptor-1 Signaling via Biased Agonism.

Liu S, Jean-Alphonse FG, White AD, Wootten D, Sexton PM, Gardella TJ, Vilardaga JP, Gellman SH. Liu S, et al. J Am Chem Soc. 2019 Sep 18;141(37):14486-14490. doi: 10.1021/jacs.9b04179. Epub 2019 Sep 9. J Am Chem Soc. 2019. PMID: 31496241 Free PMC article.

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