Shining light on location-biased cAMP signaling

Abstract

cAMP is the indispensable second messenger regulating cell metabolism and function in response to extracellular hormones and neurotransmitters. cAMP is produced via the activation of G protein-coupled receptors located at both the cell surface and inside the cell. Recently, Tsvetanova et al. explored cAMP generation in distinct locations and the impact on respective cell functions. Using a phospho-proteomic analysis, they provide insight into the unique role of localized cAMP production in cellular phospho-responses.

Keywords: G protein-coupled receptor; adenylate cyclases; cAMP; endosomal signaling; hormones; location bias; phosphoproteome.