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A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing.
Karunakaran MM, Subramanian H, Jin Y, Mohammed F, Kimmel B, Juraske C, Starick L, Nöhren A, Länder N, Willcox CR, Singh R, Schamel WW, Nikolaev VO, Kunzmann V, Wiemer AJ, Willcox BE, Herrmann T. Karunakaran MM, et al. Nat Commun. 2023 Nov 22;14(1):7617. doi: 10.1038/s41467-023-41938-8. Nat Commun. 2023. PMID: 37993425 Free PMC article.
Division of labor and cooperation between different butyrophilin proteins controls phosphoantigen-mediated activation of human γδ T cells.
Karunakaran MM, Subramanian H, Jin Y, Mohammed F, Kimmel B, Juraske C, Starick L, Nöhren A, Länder N, Willcox CR, Singh R, Schamel WW, Nikolaev VO, Kunzmann V, Wiemer AJ, Willcox BE, Herrmann T. Karunakaran MM, et al. Res Sq [Preprint]. 2023 Feb 15:rs.3.rs-2583246. doi: 10.21203/rs.3.rs-2583246/v1. Res Sq. 2023. PMID: 36824912 Free PMC article. Updated. Preprint.
Efficiency of bis-amidate phosphonate prodrugs.
Lentini NA, Huang X, Schladetsch MA, Hsiao CC, Wiemer DF, Wiemer AJ. Lentini NA, et al. Bioorg Med Chem Lett. 2022 Jun 15;66:128724. doi: 10.1016/j.bmcl.2022.128724. Epub 2022 Apr 8. Bioorg Med Chem Lett. 2022. PMID: 35405283 Free PMC article.
Stepping forward in antibody-drug conjugate development.
Jin Y, Schladetsch MA, Huang X, Balunas MJ, Wiemer AJ. Jin Y, et al. Pharmacol Ther. 2022 Jan;229:107917. doi: 10.1016/j.pharmthera.2021.107917. Epub 2021 Jun 24. Pharmacol Ther. 2022. PMID: 34171334 Free PMC article. Review.
Incorporation of a FRET pair within a phosphonate diester.
Harmon NM, Huang X, Hsiao CC, Wiemer AJ, Wiemer DF. Harmon NM, et al. Bioorg Chem. 2021 Sep;114:105048. doi: 10.1016/j.bioorg.2021.105048. Epub 2021 May 30. Bioorg Chem. 2021. PMID: 34126576 Free PMC article.