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Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis.
Lauwaet T, Miyamoto Y, Ihara S, Le C, Kalisiak J, Korthals KA, Ghassemian M, Smith DK, Sharpless KB, Fokin VV, Eckmann L. Lauwaet T, et al. PLoS Negl Trop Dis. 2020 Apr 17;14(4):e0008224. doi: 10.1371/journal.pntd.0008224. eCollection 2020 Apr. PLoS Negl Trop Dis. 2020. PMID: 32302296 Free PMC article.
20S Proteasome as a Drug Target in Trichomonas vaginalis.
O'Donoghue AJ, Bibo-Verdugo B, Miyamoto Y, Wang SC, Yang JZ, Zuill DE, Matsuka S, Jiang Z, Almaliti J, Caffrey CR, Gerwick WH, Eckmann L. O'Donoghue AJ, et al. Antimicrob Agents Chemother. 2019 Oct 22;63(11):e00448-19. doi: 10.1128/AAC.00448-19. Print 2019 Nov. Antimicrob Agents Chemother. 2019. PMID: 31451503 Free PMC article.
Metronidazole-triazole conjugates: activity against Clostridium difficile and parasites.
Jarrad AM, Karoli T, Debnath A, Tay CY, Huang JX, Kaeslin G, Elliott AG, Miyamoto Y, Ramu S, Kavanagh AM, Zuegg J, Eckmann L, Blaskovich MA, Cooper MA. Jarrad AM, et al. Eur J Med Chem. 2015 Aug 28;101:96-102. doi: 10.1016/j.ejmech.2015.06.019. Epub 2015 Jun 18. Eur J Med Chem. 2015. PMID: 26117821 Free PMC article.