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Year | Number of Results |
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2016 | 2 |
2018 | 1 |
2020 | 2 |
2021 | 2 |
2024 | 0 |
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7 results
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Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease.
Nat Aging. 2021 Oct;1(10):932-947. doi: 10.1038/s43587-021-00122-7. Epub 2021 Oct 11.
Nat Aging. 2021.
PMID: 36172600
Free PMC article.
Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer's disease.
Zalocusky KA, Najm R, Taubes AL, Hao Y, Yoon SY, Koutsodendris N, Nelson MR, Rao A, Bennett DA, Bant J, Amornkul DJ, Xu Q, An A, Cisne-Thomson O, Huang Y.
Zalocusky KA, et al.
Nat Neurosci. 2021 Jun;24(6):786-798. doi: 10.1038/s41593-021-00851-3. Epub 2021 May 6.
Nat Neurosci. 2021.
PMID: 33958804
Free PMC article.
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In Vivo Chimeric Alzheimer's Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons.
Najm R, Zalocusky KA, Zilberter M, Yoon SY, Hao Y, Koutsodendris N, Nelson M, Rao A, Taubes A, Jones EA, Huang Y.
Najm R, et al.
Cell Rep. 2020 Jul 28;32(4):107962. doi: 10.1016/j.celrep.2020.107962.
Cell Rep. 2020.
PMID: 32726626
Free PMC article.
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Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease.
Najm R, Rao A, Huang Y.
Najm R, et al.
Cell Stem Cell. 2020 Mar 5;26(3):297-299. doi: 10.1016/j.stem.2020.02.004.
Cell Stem Cell. 2020.
PMID: 32142656
Free article.
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Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector.
Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H, Li G, Miller ZA, Miller BL, Malloy MJ, Huang Y.
Wang C, et al.
Nat Med. 2018 May;24(5):647-657. doi: 10.1038/s41591-018-0004-z. Epub 2018 Apr 9.
Nat Med. 2018.
PMID: 29632371
Free PMC article.
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Apolipoprotein E4 Causes Age-Dependent Disruption of Slow Gamma Oscillations during Hippocampal Sharp-Wave Ripples.
Gillespie AK, Jones EA, Lin YH, Karlsson MP, Kay K, Yoon SY, Tong LM, Nova P, Carr JS, Frank LM, Huang Y.
Gillespie AK, et al.
Neuron. 2016 May 18;90(4):740-51. doi: 10.1016/j.neuron.2016.04.009. Epub 2016 May 5.
Neuron. 2016.
PMID: 27161522
Free PMC article.
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Enhancing GABA Signaling during Middle Adulthood Prevents Age-Dependent GABAergic Interneuron Decline and Learning and Memory Deficits in ApoE4 Mice.
Tong LM, Yoon SY, Andrews-Zwilling Y, Yang A, Lin V, Lei H, Huang Y.
Tong LM, et al.
J Neurosci. 2016 Feb 17;36(7):2316-22. doi: 10.1523/JNEUROSCI.3815-15.2016.
J Neurosci. 2016.
PMID: 26888940
Free PMC article.
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