Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease

Ramsey Najm; Antara Rao; Yadong Huang

doi:10.1016/j.stem.2020.02.004

Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease

Cell Stem Cell. 2020 Mar 5;26(3):297-299. doi: 10.1016/j.stem.2020.02.004.

Authors

Ramsey Najm¹, Antara Rao¹, Yadong Huang²

Affiliations

¹ Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, CA 94143, USA.
² Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA; Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco, CA 94143, USA; Departments of Neurology and Pathology, University of California, San Francisco, CA 94143, USA. Electronic address: yadong.huang@gladstone.ucsf.edu.

PMID: 32142656
DOI: 10.1016/j.stem.2020.02.004

Abstract

Understanding why adult hippocampal neurogenesis (AHN) is impaired in Alzheimer's disease (AD) is essential for unravelling its role in pathogenesis. In this issue of Cell Stem Cell, Zheng et al. (2020) report that human tau accumulation in dentate gyrus GABAergic interneurons disrupts AHN and strengthening GABAergic signaling restores AHN and improves cognition in an AD mouse model.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Adult
Alzheimer Disease*
Animals
Cognition
Disease Models, Animal
Hippocampus
Humans
Interneurons
Mice
Neurogenesis

Abstract

Publication types

MeSH terms

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