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Development of benzodioxine-heteroarylpiperazines as highly potent and selective α2c antagonists.
Bioorg Med Chem Lett. 2022 Dec 1;77:129005. doi: 10.1016/j.bmcl.2022.129005. Epub 2022 Sep 26.
Bioorg Med Chem Lett. 2022.
PMID: 36174834
2,3-Dihydrobenzo-dioxine piperidine derivatives as potent and selective α2c antagonists.
Wang S, Haikarainen A, Pohjakallio A, Sipilä J, Kaskinoro J, Juhila S, Jalava N, Koskinen M, Vesajoki M, Kumpulainen E, Pystynen J, Koskelainen T, Holm P, Din Belle D.
Wang S, et al. Among authors: pystynen j.
Bioorg Med Chem Lett. 2022 Aug 1;69:128783. doi: 10.1016/j.bmcl.2022.128783. Epub 2022 May 13.
Bioorg Med Chem Lett. 2022.
PMID: 35569686
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Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor.
Rautio J, Leppänen J, Lehtonen M, Laine K, Koskinen M, Pystynen J, Savolainen J, Sairanen M.
Rautio J, et al. Among authors: pystynen j.
Bioorg Med Chem Lett. 2010 Apr 15;20(8):2614-6. doi: 10.1016/j.bmcl.2010.02.057. Epub 2010 Feb 19.
Bioorg Med Chem Lett. 2010.
PMID: 20231095
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Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors.
Bäckström R, Honkanen E, Pippuri A, Kairisalo P, Pystynen J, Heinola K, Nissinen E, Linden IB, Männistö PT, Kaakkola S, et al.
Bäckström R, et al. Among authors: pystynen j.
J Med Chem. 1989 Apr;32(4):841-6. doi: 10.1021/jm00124a017.
J Med Chem. 1989.
PMID: 2704029
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Discovery and structural characterization of a phospholamban-binding cyclic peptide and design of novel inhibitors of phospholamban.
Tilgmann C, Pollesello P, Ovaska M, Kaivola J, Pystynen J, Tiainen E, Yliperttula M, Annila A, Levijoki J.
Tilgmann C, et al. Among authors: pystynen j.
Chem Biol Drug Des. 2013 Apr;81(4):463-73. doi: 10.1111/j.1747-0285.2012.01409.x. Epub 2012 Jun 6.
Chem Biol Drug Des. 2013.
PMID: 22578098
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