Development of benzodioxine-heteroarylpiperazines as highly potent and selective α2c antagonists

Abstract

Here is reported the design and synthesis of a series of highly potent and selective α2C antagonists using benzodioxine methyl piperazine as a central scaffold by pharmacophoric analysis to improve the pharmacokinetics of suboptimal clinical candidate molecules.

Keywords: (Benzodioxine); (Piperazine); (α2c Antagonist); α(2)-Adrenoceptors.