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Single-site glycine-specific labeling of proteins.
Purushottam L, Adusumalli SR, Singh U, Unnikrishnan VB, Rawale DG, Gujrati M, Mishra RK, Rai V. Purushottam L, et al. Nat Commun. 2019 Jun 10;10(1):2539. doi: 10.1038/s41467-019-10503-7. Nat Commun. 2019. PMID: 31182711 Free PMC article.
A single amino acid Gly-tag enables metal-free protein purification.
Purushottam L, V B U, Rawale DG, Gujrati M, Mishra SD, T K S, Reddy NC, Adusumalli SR, Mishra RK, Rai V. Purushottam L, et al. Chem Sci. 2020 Oct 26;11(48):13137-13142. doi: 10.1039/d0sc01153c. Chem Sci. 2020. PMID: 34094495 Free PMC article.
Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.
Zheng N, Christensen SB, Dowell C, Purushottam L, Skalicky JJ, McIntosh JM, Chou DH. Zheng N, et al. Among authors: purushottam l. J Med Chem. 2021 Jul 8;64(13):9513-9524. doi: 10.1021/acs.jmedchem.1c00802. Epub 2021 Jun 23. J Med Chem. 2021. PMID: 34161094 Free PMC article.