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Single-site glycine-specific labeling of proteins.
Nat Commun. 2019 Jun 10;10(1):2539. doi: 10.1038/s41467-019-10503-7.
Nat Commun. 2019.
PMID: 31182711
Free PMC article.
Chemoselective and Site-Selective Lysine-Directed Lysine Modification Enables Single-Site Labeling of Native Proteins.
Adusumalli SR, Rawale DG, Thakur K, Purushottam L, Reddy NC, Kalra N, Shukla S, Rai V.
Adusumalli SR, et al. Among authors: purushottam l.
Angew Chem Int Ed Engl. 2020 Jun 22;59(26):10332-10336. doi: 10.1002/anie.202000062. Epub 2020 Apr 20.
Angew Chem Int Ed Engl. 2020.
PMID: 32171045
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Chemoselective and site-selective peptide and native protein modification enabled by aldehyde auto-oxidation.
Purushottam L, Adusumalli SR, Chilamari M, Rai V.
Purushottam L, et al.
Chem Commun (Camb). 2017 Jan 16;53(5):959-962. doi: 10.1039/c6cc09555k. Epub 2017 Jan 3.
Chem Commun (Camb). 2017.
PMID: 28044167
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Site-Selective Labeling of Native Proteins by a Multicomponent Approach.
Chilamari M, Purushottam L, Rai V.
Chilamari M, et al. Among authors: purushottam l.
Chemistry. 2017 Mar 17;23(16):3819-3823. doi: 10.1002/chem.201605938. Epub 2017 Feb 27.
Chemistry. 2017.
PMID: 28177162
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A single amino acid Gly-tag enables metal-free protein purification.
Purushottam L, V B U, Rawale DG, Gujrati M, Mishra SD, T K S, Reddy NC, Adusumalli SR, Mishra RK, Rai V.
Purushottam L, et al.
Chem Sci. 2020 Oct 26;11(48):13137-13142. doi: 10.1039/d0sc01153c.
Chem Sci. 2020.
PMID: 34094495
Free PMC article.
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Synthesis and Characterization of Phenylboronic Acid-Modified Insulin With Glucose-Dependent Solubility.
Lin NP, Zheng N, Purushottam L, Zhang YW, Chou DH.
Lin NP, et al. Among authors: purushottam l.
Front Chem. 2022 Mar 16;10:859133. doi: 10.3389/fchem.2022.859133. eCollection 2022.
Front Chem. 2022.
PMID: 35372263
Free PMC article.
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Discovery of Methylene Thioacetal-Incorporated α-RgIA Analogues as Potent and Stable Antagonists of the Human α9α10 Nicotinic Acetylcholine Receptor for the Treatment of Neuropathic Pain.
Zheng N, Christensen SB, Dowell C, Purushottam L, Skalicky JJ, McIntosh JM, Chou DH.
Zheng N, et al. Among authors: purushottam l.
J Med Chem. 2021 Jul 8;64(13):9513-9524. doi: 10.1021/acs.jmedchem.1c00802. Epub 2021 Jun 23.
J Med Chem. 2021.
PMID: 34161094
Free PMC article.
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Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors.
Zheng N, Christensen SB, Blakely A, Dowell C, Purushottam L, McIntosh JM, Chou DH.
Zheng N, et al. Among authors: purushottam l.
J Med Chem. 2020 Aug 13;63(15):8380-8387. doi: 10.1021/acs.jmedchem.0c00613. Epub 2020 Jul 16.
J Med Chem. 2020.
PMID: 32597184
Free PMC article.
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