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Phase Separation in Biology and Disease; Current Perspectives and Open Questions.
Boeynaems S, Chong S, Gsponer J, Holt L, Milovanovic D, Mitrea DM, Mueller-Cajar O, Portz B, Reilly JF, Reinkemeier CD, Sabari BR, Sanulli S, Shorter J, Sontag E, Strader L, Stachowiak J, Weber SC, White M, Zhang H, Zweckstetter M, Elbaum-Garfinkle S, Kriwacki R. Boeynaems S, et al. Among authors: portz b. J Mol Biol. 2023 Mar 1;435(5):167971. doi: 10.1016/j.jmb.2023.167971. Epub 2023 Jan 21. J Mol Biol. 2023. PMID: 36690068 Free PMC article.
3' UTRs in the Eye of the TIGER.
Portz B, Shorter J. Portz B, et al. Dev Cell. 2018 Dec 3;47(5):544-546. doi: 10.1016/j.devcel.2018.11.022. Dev Cell. 2018. PMID: 30513300 Free article.
Switching Condensates: The CTD Code Goes Liquid.
Portz B, Shorter J. Portz B, et al. Trends Biochem Sci. 2020 Jan;45(1):1-3. doi: 10.1016/j.tibs.2019.10.009. Epub 2019 Nov 13. Trends Biochem Sci. 2020. PMID: 31734037
FUS and TDP-43 Phases in Health and Disease.
Portz B, Lee BL, Shorter J. Portz B, et al. Trends Biochem Sci. 2021 Jul;46(7):550-563. doi: 10.1016/j.tibs.2020.12.005. Epub 2021 Jan 11. Trends Biochem Sci. 2021. PMID: 33446423 Free PMC article. Review.
RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.
Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ. Mann JR, et al. Among authors: portz b. Neuron. 2019 Apr 17;102(2):321-338.e8. doi: 10.1016/j.neuron.2019.01.048. Epub 2019 Feb 27. Neuron. 2019. PMID: 30826182 Free PMC article.
CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation.
Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, Cleveland DW, Qiu Z, Rothstein JD, Shorter J, Gao FB, Bassik MC, Sun S. Cheng W, et al. Among authors: portz b. Neuron. 2019 Dec 4;104(5):885-898.e8. doi: 10.1016/j.neuron.2019.09.003. Epub 2019 Oct 3. Neuron. 2019. PMID: 31587919 Free PMC article.
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly.
Sweeney KM, Chantarawong S, Barbieri EM, Cajka G, Liu M, Spruce L, Fazelinia H, Portz B, Copley K, Lapidot T, Duhamel L, Greenwald P, Saida N, Shalgi R, Shorter J, Shalem O. Sweeney KM, et al. Among authors: portz b. PLoS Genet. 2024 Feb 5;20(2):e1011138. doi: 10.1371/journal.pgen.1011138. eCollection 2024 Feb. PLoS Genet. 2024. PMID: 38315730 Free PMC article.
TDP-43 condensation properties specify its RNA-binding and regulatory repertoire.
Hallegger M, Chakrabarti AM, Lee FCY, Lee BL, Amalietti AG, Odeh HM, Copley KE, Rubien JD, Portz B, Kuret K, Huppertz I, Rau F, Patani R, Fawzi NL, Shorter J, Luscombe NM, Ule J. Hallegger M, et al. Among authors: portz b. Cell. 2021 Sep 2;184(18):4680-4696.e22. doi: 10.1016/j.cell.2021.07.018. Epub 2021 Aug 10. Cell. 2021. PMID: 34380047 Free PMC article.
33 results