3' UTRs in the Eye of the TIGER

Bede Portz; James Shorter

doi:10.1016/j.devcel.2018.11.022

3' UTRs in the Eye of the TIGER

Dev Cell. 2018 Dec 3;47(5):544-546. doi: 10.1016/j.devcel.2018.11.022.

Authors

Bede Portz¹, James Shorter²

Affiliations

¹ Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.
² Department of Biochemistry and Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: jshorter@pennmedicine.upenn.edu.

PMID: 30513300
DOI: 10.1016/j.devcel.2018.11.022

Abstract

Many human genes generate mRNAs with alternative 3' untranslated regions (3' UTRs), which can modulate protein function. In a recent Cell paper, Ma and Mayr (2018) unveil a major membraneless organelle, termed the TIS granule-endoplasmic reticulum (TIGER), which enables specific 3' UTRs to encipher protein localization.

Publication types

Comment

MeSH terms

3' Untranslated Regions
Animals
Endoplasmic Reticulum*
Humans
Protein Transport
RNA, Messenger / genetics

Substances

3' Untranslated Regions
RNA, Messenger