Plise E - Search Results

1

Structure-based optimization of pyrazolo-pyrimidine and -pyridine inhibitors of PI3-kinase.

Staben ST, Heffron TP, Sutherlin DP, Bhat SR, Castanedo GM, Chuckowree IS, Dotson J, Folkes AJ, Friedman LS, Lee L, Lesnick J, Lewis C, Murray JM, Nonomiya J, Olivero AG, Plise E, Pang J, Prior WW, Salphati L, Rouge L, Sampath D, Tsui V, Wan NC, Wang S, Weismann C, Wu P, Zhu BY. Staben ST, et al. Among authors: plise e. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6048-51. doi: 10.1016/j.bmcl.2010.08.067. Epub 2010 Aug 19. Bioorg Med Chem Lett. 2010. PMID: 20822905

2

Expression and activity of the efflux transporters ABCB1, ABCC2 and ABCG2 in the human colorectal carcinoma cell line LS513.

Salphati L, Plise EG, Li G. Salphati L, et al. Eur J Pharm Sci. 2009 Jun 28;37(3-4):463-8. doi: 10.1016/j.ejps.2009.04.001. Epub 2009 Apr 9. Eur J Pharm Sci. 2009. PMID: 19491037

3

Role of P-glycoprotein and breast cancer resistance protein-1 in the brain penetration and brain pharmacodynamic activity of the novel phosphatidylinositol 3-kinase inhibitor GDC-0941.

Salphati L, Lee LB, Pang J, Plise EG, Zhang X. Salphati L, et al. Drug Metab Dispos. 2010 Sep;38(9):1422-6. doi: 10.1124/dmd.110.034256. Epub 2010 Jun 3. Drug Metab Dispos. 2010. PMID: 20522663

4

Semi-automated protein binding methodology using equilibrium dialysis and a novel mixed-matrix cassette approach.

Plise EG, Tran D, Salphati L. Plise EG, et al. J Pharm Sci. 2010 Dec;99(12):5070-8. doi: 10.1002/jps.22188. J Pharm Sci. 2010. PMID: 20821380

5

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway.

Castanedo GM, Wang S, Robarge KD, Blackwood E, Burdick D, Chang C, Dijkgraaf GJ, Gould S, Gunzner J, Guichert O, Halladay J, Khojasteh C, Lee L, Marsters JC Jr, Murray L, Peterson D, Plise E, Salphati L, de Sauvage FJ, Wong S, Sutherlin DP. Castanedo GM, et al. Among authors: plise e. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6748-53. doi: 10.1016/j.bmcl.2010.08.134. Epub 2010 Sep 15. Bioorg Med Chem Lett. 2010. PMID: 20875741

6

Preclinical absorption, distribution, metabolism, excretion, and pharmacokinetic-pharmacodynamic modelling of N-(4-(3-((3S,4R)-1-ethyl-3-fluoropiperidine-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenyl)-2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxamide, a novel MET kinase inhibitor.

Liederer BM, Berezhkovskiy LM, Dean BJ, Dinkel V, Peng J, Merchant M, Plise EG, Wong H, Liu X. Liederer BM, et al. Xenobiotica. 2011 Apr;41(4):327-39. doi: 10.3109/00498254.2010.542500. Epub 2010 Dec 23. Xenobiotica. 2011. PMID: 21182395

7

Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449).

Giannetti AM, Wong H, Dijkgraaf GJ, Dueber EC, Ortwine DF, Bravo BJ, Gould SE, Plise EG, Lum BL, Malhi V, Graham RA. Giannetti AM, et al. Among authors: plise eg. J Med Chem. 2011 Apr 28;54(8):2592-601. doi: 10.1021/jm1008924. Epub 2011 Mar 25. J Med Chem. 2011. PMID: 21438527

8

Preclinical pharmacokinetics of the novel PI3K inhibitor GDC-0941 and prediction of its pharmacokinetics and efficacy in human.

Salphati L, Pang J, Plise EG, Chou B, Halladay JS, Olivero AG, Rudewicz PJ, Tian Q, Wong S, Zhang X. Salphati L, et al. Xenobiotica. 2011 Dec;41(12):1088-99. doi: 10.3109/00498254.2011.603386. Epub 2011 Aug 13. Xenobiotica. 2011. PMID: 21838594

9

Preclinical stereoselective disposition and toxicokinetics of two novel MET inhibitors.

Liederer BM, Liu X, Berezhkovskiy LM, Cain G, Ding X, Gaudino J, Kaus R, Plise EG, Sutherlin DP, Harstad EB. Liederer BM, et al. Xenobiotica. 2012 May;42(5):456-65. doi: 10.3109/00498254.2011.632697. Epub 2011 Nov 28. Xenobiotica. 2012. PMID: 22122353

10

Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys.

Pai R, French D, Ma N, Hotzel K, Plise E, Salphati L, Setchell KD, Ware J, Lauriault V, Schutt L, Hartley D, Dambach D. Pai R, et al. Among authors: plise e. Toxicol Sci. 2012 Apr;126(2):446-56. doi: 10.1093/toxsci/kfs011. Epub 2012 Jan 19. Toxicol Sci. 2012. PMID: 22268002

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