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Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming.
Grandjean JMD, Madhavan A, Cech L, Seguinot BO, Paxman RJ, Smith E, Scampavia L, Powers ET, Cooley CB, Plate L, Spicer TP, Kelly JW, Wiseman RL. Grandjean JMD, et al. Among authors: plate l. Nat Chem Biol. 2020 Oct;16(10):1052-1061. doi: 10.1038/s41589-020-0584-z. Epub 2020 Jul 20. Nat Chem Biol. 2020. PMID: 32690944 Free PMC article.
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.
Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, Kelly JW. Chen W, et al. Among authors: plate l. J Am Chem Soc. 2016 Jun 15;138(23):7353-64. doi: 10.1021/jacs.6b02960. Epub 2016 Jun 2. J Am Chem Soc. 2016. PMID: 27191344 Free PMC article.
Modulating protein quality control.
Plate L, Paxman RJ, Wiseman RL, Kelly JW. Plate L, et al. Elife. 2016 Jul 20;5:e18431. doi: 10.7554/eLife.18431. Elife. 2016. PMID: 27435959 Free PMC article.
89 results