Modulating protein quality control

Lars Plate; Ryan J Paxman; R Luke Wiseman; Jeffery W Kelly

doi:10.7554/eLife.18431

Modulating protein quality control

Elife. 2016 Jul 20:5:e18431. doi: 10.7554/eLife.18431.

Authors

Lars Plate^{1

2}, Ryan J Paxman¹, R Luke Wiseman^{2

3}, Jeffery W Kelly^{1

2}

Affiliations

¹ Department of Chemistry, The Scripps Research Institute, La Jolla, United States.
² Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States.
³ Department of Chemical Physiology, The Scripps Research Institute, La Jolla, United States.

Abstract

Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.

Keywords: ATF6-alpha; ER stress; cell biology; endoplasmic reticulum; human; site-1-protease; small molecule screening; unfolded protein response.

Publication types

Comment

MeSH terms

Activating Transcription Factor 6 / genetics*
Humans
Proteostasis Deficiencies*
Unfolded Protein Response
eIF-2 Kinase / genetics

Substances

Activating Transcription Factor 6
eIF-2 Kinase