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Year Number of Results
2009 1
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2012 1
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2024 3

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Page 1
TNIK inhibition sensitizes TNIK-overexpressing lung squamous cell carcinoma to radiotherapy.
Nguyen T, Carrieri FA, Connis N, Lafargue A, Chang J, Chan A, Shetty AC, Song Y, Hoang T, Jagtap S, Chowdhury DD, Khan MA, Gabrielson KL, Rezaee M, Torres-Ayuso P, Brognard J, Hann CL, Tran PT. Nguyen T, et al. Among authors: torres ayuso p. Mol Cancer Ther. 2024 Apr 27. doi: 10.1158/1535-7163.MCT-23-0412. Online ahead of print. Mol Cancer Ther. 2024. PMID: 38670554
A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models.
Ren F, Aliper A, Chen J, Zhao H, Rao S, Kuppe C, Ozerov IV, Zhang M, Witte K, Kruse C, Aladinskiy V, Ivanenkov Y, Polykovskiy D, Fu Y, Babin E, Qiao J, Liang X, Mou Z, Wang H, Pun FW, Ayuso PT, Veviorskiy A, Song D, Liu S, Zhang B, Naumov V, Ding X, Kukharenko A, Izumchenko E, Zhavoronkov A. Ren F, et al. Among authors: ayuso pt. Nat Biotechnol. 2024 Mar 8. doi: 10.1038/s41587-024-02143-0. Online ahead of print. Nat Biotechnol. 2024. PMID: 38459338
PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer.
Torres-Ayuso P, Katerji M, Mehlich D, Lookingbill SA, Sabbasani VR, Liou H, Casillas AL, Chauhan SS, Serwa R, Rubin MR, Marusiak AA, Swenson RE, Warfel NA, Brognard J. Torres-Ayuso P, et al. Cell Chem Biol. 2024 Feb 15;31(2):326-337.e11. doi: 10.1016/j.chembiol.2023.10.023. Epub 2023 Nov 27. Cell Chem Biol. 2024. PMID: 38016478 Free article.
TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin.
Torres-Ayuso P, An E, Nyswaner KM, Bensen RC, Ritt DA, Specht SI, Das S, Andresson T, Cachau RE, Liang RJ, Ries AL, Robinson CM, Difilippantonio S, Gouker B, Bassel L, Karim BO, Miller CJ, Turk BE, Morrison DK, Brognard J. Torres-Ayuso P, et al. Cancer Discov. 2021 Jun;11(6):1411-1423. doi: 10.1158/2159-8290.CD-20-0797. Epub 2021 Jan 25. Cancer Discov. 2021. PMID: 33495197 Free PMC article.
Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin.
Torres-Ayuso P, Sahoo S, Ashton G, An E, Simms N, Galvin M, Leong HS, Frese KK, Simpson K, Cook N, Hughes A, Miller CJ, Marais R, Dive C, Krebs MG, Brognard J. Torres-Ayuso P, et al. NPJ Genom Med. 2018 Jun 20;3:15. doi: 10.1038/s41525-018-0055-6. eCollection 2018. NPJ Genom Med. 2018. PMID: 29951225 Free PMC article.
18 results