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Targeting cancer glycosylation repolarizes tumor-associated macrophages allowing effective immune checkpoint blockade.
Stanczak MA, Rodrigues Mantuano N, Kirchhammer N, Sanin DE, Jacob F, Coelho R, Everest-Dass AV, Wang J, Trefny MP, Monaco G, Bärenwaldt A, Gray MA, Petrone A, Kashyap AS, Glatz K, Kasenda B, Normington K, Broderick J, Peng L, Pearce OMT, Pearce EL, Bertozzi CR, Zippelius A, Läubli H. Stanczak MA, et al. Among authors: pearce omt. Sci Transl Med. 2022 Nov 2;14(669):eabj1270. doi: 10.1126/scitranslmed.abj1270. Epub 2022 Nov 2. Sci Transl Med. 2022. PMID: 36322632 Free PMC article.
Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK.
Nolan J, Pearce OMT, Screen HRC, Knight MM, Verbruggen SW. Nolan J, et al. Among authors: pearce omt. Cancers (Basel). 2023 Jan 19;15(3):635. doi: 10.3390/cancers15030635. Cancers (Basel). 2023. PMID: 36765593 Free PMC article. Review.
A Self-Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer.
Liu Y, Okesola BO, Osuna de la Peña D, Li W, Lin ML, Trabulo S, Tatari M, Lawlor RT, Scarpa A, Wang W, Knight M, Loessner D, Heeschen C, Mata A, Pearce OMT. Liu Y, et al. Among authors: pearce omt. Adv Healthc Mater. 2024 Mar 12:e2301941. doi: 10.1002/adhm.202301941. Online ahead of print. Adv Healthc Mater. 2024. PMID: 38471128
Extracellular matrix educates an immunoregulatory tumor macrophage phenotype found in ovarian cancer metastasis.
Puttock EH, Tyler EJ, Manni M, Maniati E, Butterworth C, Burger Ramos M, Peerani E, Hirani P, Gauthier V, Liu Y, Maniscalco G, Rajeeve V, Cutillas P, Trevisan C, Pozzobon M, Lockley M, Rastrick J, Läubli H, White A, Pearce OMT. Puttock EH, et al. Among authors: pearce omt. Nat Commun. 2023 May 15;14(1):2514. doi: 10.1038/s41467-023-38093-5. Nat Commun. 2023. PMID: 37188691 Free PMC article.
TGFBI Production by Macrophages Contributes to an Immunosuppressive Microenvironment in Ovarian Cancer.
Lecker LSM, Berlato C, Maniati E, Delaine-Smith R, Pearce OMT, Heath O, Nichols SJ, Trevisan C, Novak M, McDermott J, Brenton JD, Cutillas PR, Rajeeve V, Hennino A, Drapkin R, Loessner D, Balkwill FR. Lecker LSM, et al. Among authors: pearce omt. Cancer Res. 2021 Nov 15;81(22):5706-5719. doi: 10.1158/0008-5472.CAN-21-0536. Epub 2021 Sep 24. Cancer Res. 2021. PMID: 34561272 Free PMC article.
38 results