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Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity.
Betti M, Catarzi D, Varano F, Falsini M, Varani K, Vincenzi F, Pasquini S, di Cesare Mannelli L, Ghelardini C, Lucarini E, Dal Ben D, Spinaci A, Bartolucci G, Menicatti M, Colotta V. Betti M, et al. Among authors: pasquini s. J Med Chem. 2019 Aug 8;62(15):6894-6912. doi: 10.1021/acs.jmedchem.9b00106. Epub 2019 Jul 26. J Med Chem. 2019. PMID: 31306001
The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles.
Squarcialupi L, Betti M, Catarzi D, Varano F, Falsini M, Ravani A, Pasquini S, Vincenzi F, Salmaso V, Sturlese M, Varani K, Moro S, Colotta V. Squarcialupi L, et al. Among authors: pasquini s. J Enzyme Inhib Med Chem. 2017 Dec;32(1):248-263. doi: 10.1080/14756366.2016.1247060. J Enzyme Inhib Med Chem. 2017. PMID: 28114825 Free PMC article.
Development of novel pyridazinone-based adenosine receptor ligands.
Catarzi D, Varano F, Falsini M, Varani K, Vincenzi F, Pasquini S, Dal Ben D, Colotta V. Catarzi D, et al. Among authors: pasquini s. Bioorg Med Chem Lett. 2018 May 15;28(9):1484-1489. doi: 10.1016/j.bmcl.2018.03.086. Epub 2018 Mar 30. Bioorg Med Chem Lett. 2018. PMID: 29627261
Structure-activity relationship studies and pharmacological characterization of N5-heteroarylalkyl-substituted-2-(2-furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine-based derivatives as inverse agonists at human A2A adenosine receptor.
Varano F, Catarzi D, Vincenzi F, Falsini M, Pasquini S, Borea PA, Colotta V, Varani K. Varano F, et al. Among authors: pasquini s. Eur J Med Chem. 2018 Jul 15;155:552-561. doi: 10.1016/j.ejmech.2018.06.020. Epub 2018 Jun 9. Eur J Med Chem. 2018. PMID: 29909340
96 results