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Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action.
Onyeibor O, Croft SL, Dodson HI, Feiz-Haddad M, Kendrick H, Millington NJ, Parapini S, Phillips RM, Seville S, Shnyder SD, Taramelli D, Wright CW. Onyeibor O, et al. Among authors: parapini s. J Med Chem. 2005 Apr 7;48(7):2701-9. doi: 10.1021/jm040893w. J Med Chem. 2005. PMID: 15801861 Free article.
Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action.
Chadwick J, Amewu RK, Marti F, Garah FB, Sharma R, Berry NG, Stocks PA, Burrell-Saward H, Wittlin S, Rottmann M, Brun R, Taramelli D, Parapini S, Ward SA, O'Neill PM. Chadwick J, et al. Among authors: parapini s. ChemMedChem. 2011 Aug 1;6(8):1357-61. doi: 10.1002/cmdc.201100196. Epub 2011 Jun 20. ChemMedChem. 2011. PMID: 21692184 No abstract available.
Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA. O'Neill PM, et al. Among authors: parapini s. J Med Chem. 2009 Apr 9;52(7):1828-44. doi: 10.1021/jm8012757. J Med Chem. 2009. PMID: 19284751 Free article.
Antitubercular activity of quinolizidinyl/pyrrolizidinylalkyliminophenazines.
Tonelli M, Novelli F, Tasso B, Sparatore A, Boido V, Sparatore F, Cannas S, Molicotti P, Zanetti S, Parapini S, Loddo R. Tonelli M, et al. Among authors: parapini s. Bioorg Med Chem. 2014 Dec 15;22(24):6837-45. doi: 10.1016/j.bmc.2014.10.035. Epub 2014 Oct 31. Bioorg Med Chem. 2014. PMID: 25464882
106 results