Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action

ChemMedChem. 2011 Aug 1;6(8):1357-61. doi: 10.1002/cmdc.201100196. Epub 2011 Jun 20.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Amodiaquine / chemistry
  • Amodiaquine / pharmacokinetics
  • Amodiaquine / therapeutic use
  • Animals
  • Antimalarials / chemistry*
  • Antimalarials / pharmacokinetics
  • Antimalarials / therapeutic use
  • Hemeproteins / antagonists & inhibitors
  • Hemeproteins / metabolism
  • Hemin / chemistry
  • Humans
  • Malaria / drug therapy*
  • Mannich Bases / chemistry
  • Mice
  • Molecular Dynamics Simulation
  • Peroxides / chemistry
  • Phenols / chemistry
  • Plasmodium falciparum / drug effects
  • Spiro Compounds / chemistry*
  • Structure-Activity Relationship
  • Tetraoxanes / chemistry*

Substances

  • Antimalarials
  • Hemeproteins
  • Mannich Bases
  • Peroxides
  • Phenols
  • RKA 182
  • Spiro Compounds
  • Tetraoxanes
  • Amodiaquine
  • hemozoin
  • Hemin