Parai MK - Search Results

1

Design, synthesis, and biological and structural evaluations of novel HIV-1 protease inhibitors to combat drug resistance.

Parai MK, Huggins DJ, Cao H, Nalam MN, Ali A, Schiffer CA, Tidor B, Rana TM. Parai MK, et al. J Med Chem. 2012 Jul 26;55(14):6328-41. doi: 10.1021/jm300238h. Epub 2012 Jul 13. J Med Chem. 2012. PMID: 22708897 Free PMC article.

2

SAR and Lead Optimization of an HIV-1 Vif-APOBEC3G Axis Inhibitor.

Mohammed I, Parai MK, Jiang X, Sharova N, Singh G, Stevenson M, Rana TM. Mohammed I, et al. Among authors: parai mk. ACS Med Chem Lett. 2012 Jun 14;3(6):465-469. doi: 10.1021/ml300037k. ACS Med Chem Lett. 2012. PMID: 24533175 Free PMC article.

3

Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target.

Wilson C, Ray P, Zuccotto F, Hernandez J, Aggarwal A, Mackenzie C, Caldwell N, Taylor M, Huggett M, Mathieson M, Murugesan D, Smith A, Davis S, Cocco M, Parai MK, Acharya A, Tamaki F, Scullion P, Epemolu O, Riley J, Stojanovski L, Lopez-Román EM, Torres-Gómez PA, Toledo AM, Guijarro-Lopez L, Camino I, Engelhart CA, Schnappinger D, Massoudi LM, Lenaerts A, Robertson GT, Walpole C, Matthews D, Floyd D, Sacchettini JC, Read KD, Encinas L, Bates RH, Green SR, Wyatt PG. Wilson C, et al. Among authors: parai mk. J Med Chem. 2022 Jan 13;65(1):409-423. doi: 10.1021/acs.jmedchem.1c01586. Epub 2021 Dec 15. J Med Chem. 2022. PMID: 34910486 Free PMC article.

4

Effect of substituents on diarylmethanes for antitubercular activity.

Panda G, Parai MK, Das SK, Shagufta, Sinha M, Chaturvedi V, Srivastava AK, Manju YS, Gaikwad AN, Sinha S. Panda G, et al. Among authors: parai mk. Eur J Med Chem. 2007 Mar;42(3):410-9. doi: 10.1016/j.ejmech.2006.09.020. Epub 2006 Nov 15. Eur J Med Chem. 2007. PMID: 17112639

5

Thiophene containing triarylmethanes as antitubercular agents.

Parai MK, Panda G, Chaturvedi V, Manju YK, Sinha S. Parai MK, et al. Bioorg Med Chem Lett. 2008 Jan 1;18(1):289-92. doi: 10.1016/j.bmcl.2007.10.083. Epub 2007 Oct 30. Bioorg Med Chem Lett. 2008. PMID: 17997304

6

Thiophene containing trisubstituted methanes [TRSMs] as identified lead against Mycobacterium tuberculosis.

Singh P, Manna SK, Jana AK, Saha T, Mishra P, Bera S, Parai MK, Kumar M SL, Mondal S, Trivedi P, Chaturvedi V, Singh S, Sinha S, Panda G. Singh P, et al. Among authors: parai mk. Eur J Med Chem. 2015 May 5;95:357-68. doi: 10.1016/j.ejmech.2015.03.036. Epub 2015 Mar 18. Eur J Med Chem. 2015. PMID: 25828928

7

Mycobacterium tuberculosis Malate Synthase Structures with Fragments Reveal a Portal for Substrate/Product Exchange.

Huang HL, Krieger IV, Parai MK, Gawandi VB, Sacchettini JC. Huang HL, et al. Among authors: parai mk. J Biol Chem. 2016 Dec 30;291(53):27421-27432. doi: 10.1074/jbc.M116.750877. Epub 2016 Oct 13. J Biol Chem. 2016. PMID: 27738104 Free PMC article.

8

Application of Nazarov cyclization to access [6-5-6] and [6-5-5]tricyclic core embedded new heterocycles: an easy entry to structures related to taiwaniaquinoids.

Singh R, Parai MK, Panda G. Singh R, et al. Among authors: parai mk. Org Biomol Chem. 2009 May 7;7(9):1858-67. doi: 10.1039/b901632e. Epub 2009 Mar 27. Org Biomol Chem. 2009. PMID: 19590781

9

In vivo activity of thiophene-containing trisubstituted methanes against acute and persistent infection of non-tubercular Mycobacterium fortuitum in a murine infection model.

Kashyap VK, Gupta RK, Shrivastava R, Srivastava BS, Srivastava R, Parai MK, Singh P, Bera S, Panda G. Kashyap VK, et al. Among authors: parai mk. J Antimicrob Chemother. 2012 May;67(5):1188-97. doi: 10.1093/jac/dkr592. Epub 2012 Feb 6. J Antimicrob Chemother. 2012. PMID: 22311937

10

Additional synthesis on thiophene-containing trisubstituted methanes (TRSMs) as inhibitors of M. tuberculosis and 3D-QSAR studies.

Singh P, Saha T, Mishra P, Parai MK, Ireddy S, Lavanya Kumar M S, Krishna S, Kumar SK, Chaturvedi V, Sinha S, Siddiqi MI, Panda G. Singh P, et al. Among authors: parai mk. SAR QSAR Environ Res. 2016 Nov;27(11):911-937. doi: 10.1080/1062936X.2016.1243575. SAR QSAR Environ Res. 2016. PMID: 27885861

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