Thiophene containing triarylmethanes as antitubercular agents

Maloy Kumar Parai; Gautam Panda; Vinita Chaturvedi; Y K Manju; Sudhir Sinha

doi:10.1016/j.bmcl.2007.10.083

Thiophene containing triarylmethanes as antitubercular agents

Bioorg Med Chem Lett. 2008 Jan 1;18(1):289-92. doi: 10.1016/j.bmcl.2007.10.083. Epub 2007 Oct 30.

Authors

Maloy Kumar Parai¹, Gautam Panda, Vinita Chaturvedi, Y K Manju, Sudhir Sinha

Affiliation

¹ Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, UP, India.

PMID: 17997304
DOI: 10.1016/j.bmcl.2007.10.083

Abstract

A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37R(v) and showed the activity in the range of 3.12-12.5 microg/mL in vitro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkylation
Antitubercular Agents / chemical synthesis*
Antitubercular Agents / chemistry
Antitubercular Agents / pharmacology*
Drug Design
Methane / analogs & derivatives*
Methane / chemical synthesis
Methane / pharmacology
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects
Thiophenes / chemical synthesis*
Thiophenes / chemistry
Thiophenes / pharmacology*
Trityl Compounds / chemical synthesis
Trityl Compounds / chemistry
Trityl Compounds / pharmacology

Substances

Antitubercular Agents
Thiophenes
Trityl Compounds
Methane