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Use of a Bile Salt Export Pump Knockdown Rat Susceptibility Model to Interrogate Mechanism of Drug-Induced Liver Toxicity.
Li Y, Evers R, Hafey MJ, Cheon K, Duong H, Lynch D, LaFranco-Scheuch L, Pacchione S, Tamburino AM, Tanis KQ, Geddes K, Holder D, Zhang NR, Kang W, Gonzalez RJ, Galijatovic-Idrizbegovic A, Pearson KM, Lebron JA, Glaab WE, Sistare FD. Li Y, et al. Among authors: pacchione s. Toxicol Sci. 2019 Jul 1;170(1):180-198. doi: 10.1093/toxsci/kfz079. Toxicol Sci. 2019. PMID: 30903168
Development and Application of a Transcriptomic Signature of Bioactivation in an Advanced In Vitro Liver Model to Reduce Drug-induced Liver Injury Risk Early in the Pharmaceutical Pipeline.
Kang W, Podtelezhnikov AA, Tanis KQ, Pacchione S, Su M, Bleicher KB, Wang Z, Laws GM, Griffiths TG, Kuhls MC, Chen Q, Knemeyer I, Marsh DJ, Mitra K, Lebron J, Sistare FD. Kang W, et al. Among authors: pacchione s. Toxicol Sci. 2020 Sep 1;177(1):121-139. doi: 10.1093/toxsci/kfaa094. Toxicol Sci. 2020. PMID: 32559289
Characterization of indoleamine-2,3-dioxygenase 1, tryptophan-2,3-dioxygenase, and Ido1/Tdo2 knockout mice.
Aslamkhan AG, Xu Q, Loughlin A, Vu H, Pacchione S, Bhatt B, Garfinkel I, Styring TG, LaFranco-Scheuch L, Pearson K, Reynolds S, Li N, Zhou H, Miller JR, Solban N, Bass A, Glaab WE. Aslamkhan AG, et al. Among authors: pacchione s. Toxicol Appl Pharmacol. 2020 Nov 1;406:115216. doi: 10.1016/j.taap.2020.115216. Epub 2020 Aug 29. Toxicol Appl Pharmacol. 2020. PMID: 32871117
Adaptation of the WHO guideline for residual DNA in parenteral vaccines produced on continuous cell lines to a limit for oral vaccines.
Lebron JA, Troilol PJ, Pacchione S, Griffiths TG, Harper LB, Mixson LA, Jackson BE, Michna L, Barnum AB, Denisova L, Johnson CN, Maurer KL, Morgan-Hoffman S, Niu Z, Roden DF, Wang Z, Wolf JJ, Hamilton TR, Laux KM, Soper KA, Ledwith BJ. Lebron JA, et al. Among authors: pacchione s. Dev Biol (Basel). 2006;123:35-44; discussion 55-73. Dev Biol (Basel). 2006. PMID: 16566435
Tumorigenicity assessments of Per.C6 cells and of an Ad5-vectored HIV-1 vaccine produced on this continuous cell line.
Ledwith BJ, Lanning CL, Gumprecht LA, Anderson CA, Coleman JB, Gatto NT, Balasubramanian G, Farris GM, Kemp RK, Harper LB, Barnum AB, Pacchione SJ, Mauer KL, Troilo PF, Brown ER, Wolf JJ, Lebronl JA, Lewis JA, Nichols WW. Ledwith BJ, et al. Among authors: pacchione sj. Dev Biol (Basel). 2006;123:251-63; discussion 265-6. Dev Biol (Basel). 2006. PMID: 16566451
17 results