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Page 1
Targeting fibroblast growth factor receptors to combat aggressive ependymoma.
Lötsch D, Kirchhofer D, Englinger B, Jiang L, Okonechnikov K, Senfter D, Laemmerer A, Gabler L, Pirker C, Donson AM, Bannauer P, Korbel P, Jaunecker CN, Hübner JM, Mayr L, Madlener S, Schmook MT, Ricken G, Maaß K, Grusch M, Holzmann K, Grasl-Kraupp B, Spiegl-Kreinecker S, Hsu J, Dorfer C, Rössler K, Azizi AA, Foreman NK, Peyrl A, Haberler C, Czech T, Slavc I, Filbin MG, Pajtler KW, Kool M, Berger W, Gojo J. Lötsch D, et al. Among authors: okonechnikov k. Acta Neuropathol. 2021 Aug;142(2):339-360. doi: 10.1007/s00401-021-02327-x. Epub 2021 May 27. Acta Neuropathol. 2021. PMID: 34046693 Free PMC article.
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling.
Mack SC, Pajtler KW, Chavez L, Okonechnikov K, Bertrand KC, Wang X, Erkek S, Federation A, Song A, Lee C, Wang X, McDonald L, Morrow JJ, Saiakhova A, Sin-Chan P, Wu Q, Michaelraj KA, Miller TE, Hubert CG, Ryzhova M, Garzia L, Donovan L, Dombrowski S, Factor DC, Luu B, Valentim CLL, Gimple RC, Morton A, Kim L, Prager BC, Lee JJY, Wu X, Zuccaro J, Thompson Y, Holgado BL, Reimand J, Ke SQ, Tropper A, Lai S, Vijayarajah S, Doan S, Mahadev V, Miñan AF, Gröbner SN, Lienhard M, Zapatka M, Huang Z, Aldape KD, Carcaboso AM, Houghton PJ, Keir ST, Milde T, Witt H, Li Y, Li CJ, Bian XW, Jones DTW, Scott I, Singh SK, Huang A, Dirks PB, Bouffet E, Bradner JE, Ramaswamy V, Jabado N, Rutka JT, Northcott PA, Lupien M, Lichter P, Korshunov A, Scacheri PC, Pfister SM, Kool M, Taylor MD, Rich JN. Mack SC, et al. Among authors: okonechnikov k. Nature. 2018 Jan 4;553(7686):101-105. doi: 10.1038/nature25169. Epub 2017 Dec 20. Nature. 2018. PMID: 29258295 Free PMC article.
Desmoplastic/nodular medulloblastomas (DNMB) and medulloblastomas with extensive nodularity (MBEN) disclose similar epigenetic signatures but different transcriptional profiles.
Korshunov A, Sahm F, Okonechnikov K, Ryzhova M, Stichel D, Schrimpf D, Casalini B, Sievers P, Meyer J, Zheludkova O, Golanov A, Lichter P, Jones DTW, Pfister SM, Kool M, von Deimling A. Korshunov A, et al. Among authors: okonechnikov k. Acta Neuropathol. 2019 Jun;137(6):1003-1015. doi: 10.1007/s00401-019-01981-6. Epub 2019 Mar 2. Acta Neuropathol. 2019. PMID: 30826918
Molecular progression of SHH-activated medulloblastomas.
Korshunov A, Okonechnikov K, Sahm F, Ryzhova M, Stichel D, Sievers P, Meyer J, Schrimpf D, Zheludkova O, Golanov A, Lichter P, Jones DTW, Pfister SM, von Deimling A, Kool M. Korshunov A, et al. Among authors: okonechnikov k. Acta Neuropathol. 2019 Aug;138(2):327-330. doi: 10.1007/s00401-019-02022-y. Epub 2019 Apr 27. Acta Neuropathol. 2019. PMID: 31030238 No abstract available.
MYCN amplification drives an aggressive form of spinal ependymoma.
Ghasemi DR, Sill M, Okonechnikov K, Korshunov A, Yip S, Schutz PW, Scheie D, Kruse A, Harter PN, Kastelan M, Wagner M, Hartmann C, Benzel J, Maass KK, Khasraw M, Sträter R, Thomas C, Paulus W, Kratz CP, Witt H, Kawauchi D, Herold-Mende C, Sahm F, Brandner S, Kool M, Jones DTW, von Deimling A, Pfister SM, Reuss DE, Pajtler KW. Ghasemi DR, et al. Among authors: okonechnikov k. Acta Neuropathol. 2019 Dec;138(6):1075-1089. doi: 10.1007/s00401-019-02056-2. Epub 2019 Aug 14. Acta Neuropathol. 2019. PMID: 31414211 Free PMC article.
YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis.
Pajtler KW, Wei Y, Okonechnikov K, Silva PBG, Vouri M, Zhang L, Brabetz S, Sieber L, Gulley M, Mauermann M, Wedig T, Mack N, Imamura Kawasawa Y, Sharma T, Zuckermann M, Andreiuolo F, Holland E, Maass K, Körkel-Qu H, Liu HK, Sahm F, Capper D, Bunt J, Richards LJ, Jones DTW, Korshunov A, Chavez L, Lichter P, Hoshino M, Pfister SM, Kool M, Li W, Kawauchi D. Pajtler KW, et al. Among authors: okonechnikov k. Nat Commun. 2019 Sep 2;10(1):3914. doi: 10.1038/s41467-019-11884-5. Nat Commun. 2019. PMID: 31477715 Free PMC article.
Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker.
Korshunov A, Okonechnikov K, Sahm F, Ryzhova M, Stichel D, Schrimpf D, Ghasemi DR, Pajtler KW, Antonelli M, Donofrio V, Mastronuzzi A, Rossi S, Camassei FD, Buccoliero AM, Haberler C, Slavc I, Dahiya S, Casalini B, Sievers P, Meyer J, Kumirova E, Zheludkova O, Golanov A, Jones DTW, Pfister SM, Kool M, von Deimling A. Korshunov A, et al. Among authors: okonechnikov k. Acta Neuropathol. 2020 Mar;139(3):583-596. doi: 10.1007/s00401-019-02102-z. Epub 2019 Nov 28. Acta Neuropathol. 2020. PMID: 31781912
The genetic landscape of choroid plexus tumors in children and adults.
Thomas C, Soschinski P, Zwaig M, Oikonomopoulos S, Okonechnikov K, Pajtler KW, Sill M, Schweizer L, Koch A, Neumann J, Schüller U, Sahm F, Rauschenbach L, Keyvani K, Proescholdt M, Riemenschneider MJ, Segewiß J, Ruckert C, Grauer O, Monoranu CM, Lamszus K, Patrizi A, Kordes U, Siebert R, Kool M, Ragoussis J, Foulkes WD, Paulus W, Rivera B, Hasselblatt M. Thomas C, et al. Among authors: okonechnikov k. Neuro Oncol. 2021 Apr 12;23(4):650-660. doi: 10.1093/neuonc/noaa267. Neuro Oncol. 2021. PMID: 33249490 Free PMC article.
Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation.
Korshunov A, Okonechnikov K, Schmitt-Hoffner F, Ryzhova M, Sahm F, Stichel D, Schrimpf D, Reuss DE, Sievers P, Suwala AK, Kumirova E, Zheludkova O, Golanov A, Jones DTW, Pfister SM, Kool M, von Deimling A. Korshunov A, et al. Among authors: okonechnikov k. Acta Neuropathol Commun. 2021 Feb 3;9(1):20. doi: 10.1186/s40478-021-01118-5. Acta Neuropathol Commun. 2021. PMID: 33536079 Free PMC article.
42 results