Molecular progression of SHH-activated medulloblastomas

Andrey Korshunov; Konstantin Okonechnikov; Felix Sahm; Marina Ryzhova; Damian Stichel; Philipp Sievers; Jochen Meyer; Daniel Schrimpf; Olga Zheludkova; Andrey Golanov; Peter Lichter; David T W Jones; Stefan M Pfister; Andreas von Deimling; Marcel Kool

doi:10.1007/s00401-019-02022-y

Molecular progression of SHH-activated medulloblastomas

Acta Neuropathol. 2019 Aug;138(2):327-330. doi: 10.1007/s00401-019-02022-y. Epub 2019 Apr 27.

Authors

Andrey Korshunov^{1

2

3}, Konstantin Okonechnikov^{4

5}, Felix Sahm^{6

7

4}, Marina Ryzhova⁸, Damian Stichel^{6

7}, Philipp Sievers^{6

7}, Jochen Meyer^{6

7}, Daniel Schrimpf^{6

7}, Olga Zheludkova⁹, Andrey Golanov¹⁰, Peter Lichter^{4

11}, David T W Jones^{4

5}, Stefan M Pfister^{4

5

12}, Andreas von Deimling^{6

7

4}, Marcel Kool^{4

5}

Affiliations

¹ Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. andrey.korshunov@med.uni-heidelberg.de.
² Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany. andrey.korshunov@med.uni-heidelberg.de.
³ Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany. andrey.korshunov@med.uni-heidelberg.de.
⁴ Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
⁵ Division of Pediatric Neurooncology (B062), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
⁶ Clinical Cooperation Unit Neuropathology (G380), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
⁷ Department of Neuropathology, Heidelberg University Hospital, Heidelberg, Germany.
⁸ Department of Neuropathology, NN Burdenko Neurosurgical Institute, Moscow, Russia.
⁹ Department of Neuro-Oncology, Russian Scientific Center of Radiology, Moscow, Russia.
¹⁰ Department of Neuroradiology, NN Burdenko Neurosurgical Institute, Moscow, Russia.
¹¹ Division of Molecular Genetics (B060), German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
¹² Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany.

PMID: 31030238
DOI: 10.1007/s00401-019-02022-y

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Cerebellar Neoplasms / genetics*
Cerebellar Neoplasms / mortality
Cerebellar Neoplasms / pathology
Cerebellar Neoplasms / therapy
Child
Child, Preschool
Combined Modality Therapy
Cranial Irradiation
DNA, Neoplasm / genetics
Disease Progression
Gene Expression Regulation, Neoplastic
Hedgehog Proteins / physiology*
Humans
Infant
Medulloblastoma / genetics*
Medulloblastoma / mortality
Medulloblastoma / pathology
Medulloblastoma / therapy
Mutation
Neoplasm Metastasis
Neoplasm Proteins / genetics
Neoplasm Proteins / physiology*
Neoplasm Recurrence, Local / pathology
Neoplasm Recurrence, Local / surgery
Patched-1 Receptor / genetics
Patched-1 Receptor / physiology
Patched-2 Receptor
RNA, Messenger / genetics
RNA, Neoplasm / genetics
Young Adult

Substances

DNA, Neoplasm
Hedgehog Proteins
Neoplasm Proteins
PTCH1 protein, human
Patched-1 Receptor
Patched-2 Receptor
RNA, Messenger
RNA, Neoplasm
SHH protein, human

Grants and funding

№18-45-06012/Russian Science Foundation/International