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Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan.
Okhina AA, Kornienko TE, Rogachev AD, Luzina OA, Popova NA, Nikolin VP, Zakharenko AL, Dyrkheeva NS, Pokrovsky AG, Salakhutdinov NF, Lavrik OI. Okhina AA, et al. J Pharm Biomed Anal. 2023 Nov 30;236:115731. doi: 10.1016/j.jpba.2023.115731. Epub 2023 Sep 18. J Pharm Biomed Anal. 2023. PMID: 37741072
Development of an LC-MS/MS-based method for quantification and pharmacokinetics study on SCID mice of a dehydroabietylamine-adamantylamine conjugate, a promising inhibitor of the DNA repair enzyme.
Okhina AA, Rogachev AD, Kovaleva KS, Yarovaya OI, Khotskina AS, Zavyalov EL, Vatsadze SZ, Pokrovsky AG, Salakhutdinov NF. Okhina AA, et al. J Pharm Biomed Anal. 2023 Sep 20;234:115507. doi: 10.1016/j.jpba.2023.115507. Epub 2023 Jun 7. J Pharm Biomed Anal. 2023. PMID: 37331915
Development and validation of an LC-MS/MS method for the quantitative analysis of the anti-influenza agent camphecene in rat plasma and its application to study the blood-to-plasma distribution of the agent.
Okhina AA, Rogachev AD, Yarovaya OI, Khvostov MV, Tolstikova TG, Pokrovsky AG, Khazanov VA, Salakhutdinov NF. Okhina AA, et al. J Pharm Biomed Anal. 2020 Feb 20;180:113039. doi: 10.1016/j.jpba.2019.113039. Epub 2019 Dec 10. J Pharm Biomed Anal. 2020. PMID: 31865208