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Pharmacokinetic study of Tdp1 inhibitor resulted in a significant increase in antitumor effect in the treatment of Lewis lung carcinoma in mice by its combination with topotecan.
J Pharm Biomed Anal. 2023 Nov 30;236:115731. doi: 10.1016/j.jpba.2023.115731. Epub 2023 Sep 18.
J Pharm Biomed Anal. 2023.
PMID: 37741072
Development of an LC-MS/MS-based method for quantification and pharmacokinetics study on SCID mice of a dehydroabietylamine-adamantylamine conjugate, a promising inhibitor of the DNA repair enzyme.
Okhina AA, Rogachev AD, Kovaleva KS, Yarovaya OI, Khotskina AS, Zavyalov EL, Vatsadze SZ, Pokrovsky AG, Salakhutdinov NF.
Okhina AA, et al.
J Pharm Biomed Anal. 2023 Sep 20;234:115507. doi: 10.1016/j.jpba.2023.115507. Epub 2023 Jun 7.
J Pharm Biomed Anal. 2023.
PMID: 37331915
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Ligand-free Ullmann-type arylation of oxazolidinones by diaryliodonium salts.
Podrezova EV, Okhina AA, Rogachev AD, Baykov SV, Kirschning A, Yusubov MS, Soldatova NS, Postnikov PS.
Podrezova EV, et al. Among authors: okhina aa.
Org Biomol Chem. 2023 Mar 1;21(9):1952-1957. doi: 10.1039/d2ob02122f.
Org Biomol Chem. 2023.
PMID: 36757159
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Novel Soloxolone Amides as Potent Anti-Glioblastoma Candidates: Design, Synthesis, In Silico Analysis and Biological Activities In Vitro and In Vivo.
Markov AV, Ilyina AA, Salomatina OV, Sen'kova AV, Okhina AA, Rogachev AD, Salakhutdinov NF, Zenkova MA.
Markov AV, et al. Among authors: okhina aa.
Pharmaceuticals (Basel). 2022 May 14;15(5):603. doi: 10.3390/ph15050603.
Pharmaceuticals (Basel). 2022.
PMID: 35631429
Free PMC article.
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Novel Bispidine-Monoterpene Conjugates-Synthesis and Application as Ligands for the Catalytic Ethylation of Chalcones.
Suslov EV, Ponomarev KY, Patrusheva OS, Kuranov SO, Okhina AA, Rogachev AD, Munkuev AA, Ottenbacher RV, Dalinger AI, Kalinin MA, Vatsadze SZ, Volcho KP, Salakhutdinov NF.
Suslov EV, et al. Among authors: okhina aa.
Molecules. 2021 Dec 13;26(24):7539. doi: 10.3390/molecules26247539.
Molecules. 2021.
PMID: 34946622
Free PMC article.
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Stability study of the antiviral agent camphecene in dried blood spots at different temperatures.
Okhina AA, Rogachev AD, Yarovaya OI, Pokrovsky AG, Salakhutdinov NF.
Okhina AA, et al.
Drug Test Anal. 2021 Oct;13(10):1797-1802. doi: 10.1002/dta.3148. Epub 2021 Aug 27.
Drug Test Anal. 2021.
PMID: 34448348
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Development and validation of an LC-MS/MS method for the quantitative analysis of the anti-influenza agent camphecene in rat plasma and its application to study the blood-to-plasma distribution of the agent.
Okhina AA, Rogachev AD, Yarovaya OI, Khvostov MV, Tolstikova TG, Pokrovsky AG, Khazanov VA, Salakhutdinov NF.
Okhina AA, et al.
J Pharm Biomed Anal. 2020 Feb 20;180:113039. doi: 10.1016/j.jpba.2019.113039. Epub 2019 Dec 10.
J Pharm Biomed Anal. 2020.
PMID: 31865208
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