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Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery.
Morimoto S, Takahashi S, Ito D, Daté Y, Okada K, Kato C, Nakamura S, Ozawa F, Chyi CM, Nishiyama A, Suzuki N, Fujimori K, Kondo T, Takao M, Hirai M, Kabe Y, Suematsu M, Jinzaki M, Aoki M, Fujiki Y, Sato Y, Suzuki N, Nakahara J; Pooled Resource Open-Access ALS Clinical Trials Consortium; Okano H. Morimoto S, et al. Among authors: okano h. Cell Stem Cell. 2023 Jun 1;30(6):766-780.e9. doi: 10.1016/j.stem.2023.04.017. Cell Stem Cell. 2023. PMID: 37267913 Free article. Clinical Trial.
Generation of a tyrosine hydroxylase-2A-Cre knockin non-human primate model by homology-directed-repair-biased CRISPR genome editing.
Yoshimatsu S, Okahara J, Yoshie J, Igarashi Y, Nakajima R, Sanosaka T, Qian E, Sato T, Kobayashi H, Morimoto S, Kishi N, Pillis DM, Malik P, Noce T, Okano H. Yoshimatsu S, et al. Among authors: okano h. Cell Rep Methods. 2023 Sep 25;3(9):100590. doi: 10.1016/j.crmeth.2023.100590. Epub 2023 Sep 14. Cell Rep Methods. 2023. PMID: 37714158 Free PMC article.
Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia.
Abe Y, Yagishita S, Sano H, Sugiura Y, Dantsuji M, Suzuki T, Mochizuki A, Yoshimaru D, Hata J, Matsumoto M, Taira S, Takeuchi H, Okano H, Ohno N, Suematsu M, Inoue T, Nambu A, Watanabe M, Tanaka KF. Abe Y, et al. Among authors: okano h. Cell Rep Med. 2023 Oct 17;4(10):101208. doi: 10.1016/j.xcrm.2023.101208. Epub 2023 Sep 28. Cell Rep Med. 2023. PMID: 37774703 Free PMC article.
Benefits of utilizing gene-modified iPSCs for clinical applications.
Ellis J, Baum C, Benvenisty N, Mostoslavsky G, Okano H, Stanford WL, Porteus M, Sadelain M. Ellis J, et al. Among authors: okano h. Cell Stem Cell. 2010 Oct 8;7(4):429-30. doi: 10.1016/j.stem.2010.09.010. Cell Stem Cell. 2010. PMID: 20887948 Free article. No abstract available.
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation.
Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Sankar N, Ng YK, Ling EA, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Aster JC, Schachner M, Pallen CJ, Watanabe K, Xiao ZC. Hu QD, et al. Among authors: okano h. Cell. 2003 Oct 17;115(2):163-75. doi: 10.1016/s0092-8674(03)00810-9. Cell. 2003. PMID: 14567914 Free article.
Human-Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Showed Neuronal Differentiation, Neurite Extension, and Formation of Synaptic Structures in Rodent Ischemic Stroke Brains.
Kanemura Y, Yamamoto A, Katsuma A, Fukusumi H, Shofuda T, Kanematsu D, Handa Y, Sumida M, Yoshioka E, Mine Y, Yamaguchi R, Okada M, Igarashi M, Sekino Y, Shirao T, Nakamura M, Okano H. Kanemura Y, et al. Among authors: okano h. Cells. 2024 Apr 12;13(8):671. doi: 10.3390/cells13080671. Cells. 2024. PMID: 38667286 Free PMC article.
1,667 results