Generation of two induced pluripotent stem cell lines from individuals without auditory disorders

Shota Okura; Honoka Ishii; Ayano Suzuki; Chika Saegusa; Ko Fujiki; Kenshi Sugano; Noriomi Suzuki; Tsubasa Saeki; Saeko Matsuzaki; Hiroyuki Ozawa; Masato Fujioka; Makoto Hosoya; Hideyuki Okano

doi:10.1016/j.scr.2023.103017

Generation of two induced pluripotent stem cell lines from individuals without auditory disorders

Stem Cell Res. 2023 Mar:67:103017. doi: 10.1016/j.scr.2023.103017. Epub 2023 Jan 4.

Authors

Affiliations

¹ Keio University School of Medicine, Japan.
² Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Japan; Department of Molecular Genetics, Kitasato University School of Medicine, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Japan.
³ Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Japan.
⁴ Department of Physiology, Keio University School of Medicine, Japan.
⁵ Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Japan; Department of Molecular Genetics, Kitasato University School of Medicine, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Japan; Clinical and Translational Research Center, Keio University Hospital, Japan.

PMID: 36630839
DOI: 10.1016/j.scr.2023.103017

Abstract

We report the establishment of two human induced pluripotent stem cell (iPSC) lines from individuals without auditory disorders. Extensive audiometry tests were performed to confirm normal hearing. The generated iPSC lines expressed pluripotency genes and showed differentiation capability into the three germ layers. The iPSC lines will be used as controls for pathological analysis and drug screening for ear disorders.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Differentiation / genetics
Humans
Induced Pluripotent Stem Cells* / metabolism