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Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.
Ohe T, Umezawa R, Kitagawara Y, Yasuda D, Takahashi K, Nakamura S, Abe A, Sekine S, Ito K, Okunushi K, Morio H, Furihata T, Anzai N, Mashino T. Ohe T, et al. Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3708-3711. doi: 10.1016/j.bmcl.2018.10.023. Epub 2018 Oct 15. Bioorg Med Chem Lett. 2018. PMID: 30389287
Substituent elimination from p-substituted phenols by cytochrome P450. ipso-Substitution by the oxygen atom of the active species.
Ohe T, Mashino T, Hirobe M. Ohe T, et al. Drug Metab Dispos. 1997 Jan;25(1):116-22. Drug Metab Dispos. 1997. PMID: 9010638
These results are similar to those in a cytochrome P450 chemical model system (Ohe, T., et al., Tetrahedron Lett. 42, 7681-7684, 1995), implying that the model is a good mimic of cytochrome P450. ...
These results are similar to those in a cytochrome P450 chemical model system (Ohe, T., et al., Tetrahedron Lett. 42, 7681-768 …
Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.
Ogino Y, Ohtake N, Nagae Y, Matsuda K, Moriya M, Suga T, Ishikawa M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T. Ogino Y, et al. Among authors: ohe t. Bioorg Med Chem Lett. 2008 Sep 15;18(18):5010-4. doi: 10.1016/j.bmcl.2008.08.018. Epub 2008 Aug 12. Bioorg Med Chem Lett. 2008. PMID: 18723347
519 results