Abstract
In the present study, we describe the synthesis of a novel set of pyridine/pyridinium-type fullerene derivatives. The products were assessed for human immunodeficiency virus-reverse transcriptase inhibition activities. All novel fullerene derivatives showed potent human immunodeficiency virus-reverse transcriptase inhibition without cytotoxicity.
Keywords:
Fullerene; HIV reverse transcriptase; Human immunodeficiency virus (HIV).
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / pharmacology*
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Cell Survival / drug effects
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Fullerenes / chemistry
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Fullerenes / pharmacology*
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HIV Reverse Transcriptase
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HL-60 Cells
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Humans
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Pyridines / chemical synthesis
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Pyridines / pharmacology*
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Pyridinium Compounds / chemical synthesis
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Pyridinium Compounds / pharmacology*
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Reverse Transcriptase Inhibitors / chemical synthesis
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Reverse Transcriptase Inhibitors / pharmacology*
Substances
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Anti-HIV Agents
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Fullerenes
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Pyridines
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Pyridinium Compounds
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Reverse Transcriptase Inhibitors
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HIV Reverse Transcriptase