The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3226-9. doi: 10.1016/j.bmcl.2015.05.086. Epub 2015 Jun 3.

Abstract

In the present study, we describe the synthesis of a novel set of pyridine/pyridinium-type fullerene derivatives. The products were assessed for human immunodeficiency virus-reverse transcriptase inhibition activities. All novel fullerene derivatives showed potent human immunodeficiency virus-reverse transcriptase inhibition without cytotoxicity.

Keywords: Fullerene; HIV reverse transcriptase; Human immunodeficiency virus (HIV).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis
  • Anti-HIV Agents / pharmacology*
  • Cell Survival / drug effects
  • Fullerenes / chemistry
  • Fullerenes / pharmacology*
  • HIV Reverse Transcriptase
  • HL-60 Cells
  • Humans
  • Pyridines / chemical synthesis
  • Pyridines / pharmacology*
  • Pyridinium Compounds / chemical synthesis
  • Pyridinium Compounds / pharmacology*
  • Reverse Transcriptase Inhibitors / chemical synthesis
  • Reverse Transcriptase Inhibitors / pharmacology*

Substances

  • Anti-HIV Agents
  • Fullerenes
  • Pyridines
  • Pyridinium Compounds
  • Reverse Transcriptase Inhibitors
  • HIV Reverse Transcriptase