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The binding of Mint/X11 PDZ domains to Ca V 2 calcium channels predates bilaterian animals.
Harracksingh AN, Singh A, Mayorova T, Bejoy B, Hornbeck J, Elkhatib W, McEdwards G, Gauberg J, Taha ARW, Islam IM, Erclik T, Currie MA, Noyes M, Senatore A. Harracksingh AN, et al. Among authors: noyes m. bioRxiv [Preprint]. 2024 Feb 29:2024.02.26.582151. doi: 10.1101/2024.02.26.582151. bioRxiv. 2024. PMID: 38463976 Free PMC article. Preprint.
Brain and cancer associated binding domain mutations provide insight into CTCF's relationship with chromatin and its ability to act as a chromatin organizer.
Do C, Jiang G, Cova G, Katsifis CC, Narducci DN, Yang J, Sakellaropoulos T, Vidal R, Lhoumaud P, Fara Regis F, Kakabadze N, Nora EP, Noyes M, Cheng X, Hansen AS, Skok JA. Do C, et al. Among authors: noyes m. bioRxiv [Preprint]. 2024 Feb 5:2024.01.11.575070. doi: 10.1101/2024.01.11.575070. bioRxiv. 2024. PMID: 38370764 Free PMC article. Preprint.
Manipulating the 3D organization of the largest synthetic yeast chromosome.
Zhang W, Lazar-Stefanita L, Yamashita H, Shen MJ, Mitchell LA, Kurasawa H, Lobzaev E, Fanfani V, Haase MAB, Sun X, Jiang Q, Goldberg GW, Ichikawa DM, Lauer SL, McCulloch LH, Easo N, Lin SJ, Camellato BR, Zhu Y, Cai J, Xu Z, Zhao Y, Sacasa M; Build-A-Genome Class; Noyes MB, Bader JS, Deutsch S, Stracquadanio G, Aizawa Y, Dai J, Boeke JD. Zhang W, et al. Among authors: noyes mb. Mol Cell. 2023 Dec 7;83(23):4424-4437.e5. doi: 10.1016/j.molcel.2023.10.015. Epub 2023 Nov 8. Mol Cell. 2023. PMID: 37944526 Free article.
Engineered transcription-associated Cas9 targeting in eukaryotic cells.
Goldberg GW, Kogenaru M, Keegan S, Haase MAB, Kagermazova L, Arias MA, Onyebeke K, Adams S, Fenyö D, Noyes MB, Boeke JD. Goldberg GW, et al. Among authors: noyes mb. bioRxiv [Preprint]. 2023 Sep 18:2023.09.18.558319. doi: 10.1101/2023.09.18.558319. bioRxiv. 2023. PMID: 37781609 Free PMC article. Preprint.
Oncogenic inspiration for programmable activators.
Ichikawa D, Noyes M. Ichikawa D, et al. Among authors: noyes m. Cell Genom. 2022 Apr 13;2(4):100122. doi: 10.1016/j.xgen.2022.100122. eCollection 2022 Apr 13. Cell Genom. 2022. PMID: 36776529 Free PMC article.
A universal deep-learning model for zinc finger design enables transcription factor reprogramming.
Ichikawa DM, Abdin O, Alerasool N, Kogenaru M, Mueller AL, Wen H, Giganti DO, Goldberg GW, Adams S, Spencer JM, Razavi R, Nim S, Zheng H, Gionco C, Clark FT, Strokach A, Hughes TR, Lionnet T, Taipale M, Kim PM, Noyes MB. Ichikawa DM, et al. Among authors: noyes mb. Nat Biotechnol. 2023 Aug;41(8):1117-1129. doi: 10.1038/s41587-022-01624-4. Epub 2023 Jan 26. Nat Biotechnol. 2023. PMID: 36702896 Free PMC article.
78 results