Oncogenic inspiration for programmable activators

David Ichikawa; Marcus Noyes

doi:10.1016/j.xgen.2022.100122

Oncogenic inspiration for programmable activators

Cell Genom. 2022 Apr 13;2(4):100122. doi: 10.1016/j.xgen.2022.100122.

Authors

David Ichikawa^{1

2}, Marcus Noyes^{1

2}

Affiliations

¹ Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, 435 East 30th Street, New York, NY 10016, USA.
² Institute for Systems Genetics, NYU Grossman School of Medicine, 435 East 30th Street, New York, NY 10016, USA.

Abstract

The discovery of regulatory domains has been limited to the investigation of transcription factors and homologous protein sequences. In this issue of Cell Genomics, motivated by an oncogenic protein fusion, Tak et al.¹ direct the regulatory potential of a nontraditional effector domain to novel genomic loci with fusions to programmable DNA-binding domains.

Publication types

News