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VNLG-152R and its deuterated analogs potently inhibit/repress triple/quadruple negative breast cancer of diverse racial origins in vitro and in vivo by upregulating E3 Ligase Synoviolin 1 (SYVN1) and inducing proteasomal degradation of MNK1/2.
Thankan RS, Thomas E, Purushottamachar P, Weber DJ, Ramamurthy VP, Huang W, Kane MA, Njar VCO. Thankan RS, et al. Among authors: njar vco. Front Oncol. 2023 Sep 11;13:1240996. doi: 10.3389/fonc.2023.1240996. eCollection 2023. Front Oncol. 2023. PMID: 37766871 Free PMC article.
Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice.
Kwegyir-Afful AK, Murigi FN, Purushottamachar P, Ramamurthy VP, Martin MS, Njar VCO. Kwegyir-Afful AK, et al. Among authors: njar vco. Oncotarget. 2016 Dec 24;8(32):52381-52402. doi: 10.18632/oncotarget.14154. eCollection 2017 Aug 8. Oncotarget. 2016. PMID: 28881737 Free PMC article.
81 results