Njar VC - Search Results

1

First MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines.

Ramalingam S, Gediya L, Kwegyir-Afful AK, Ramamurthy VP, Purushottamachar P, Mbatia H, Njar VC. Ramalingam S, et al. Among authors: njar vc. Oncotarget. 2014 Jan 30;5(2):530-43. doi: 10.18632/oncotarget.1528. Oncotarget. 2014. PMID: 24504069 Free PMC article.

2

Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.

Patel JB, Huynh CK, Handratta VD, Gediya LK, Brodie AM, Goloubeva OG, Clement OO, Nanne IP, Soprano DR, Njar VC. Patel JB, et al. Among authors: njar vc. J Med Chem. 2004 Dec 30;47(27):6716-29. doi: 10.1021/jm0401457. J Med Chem. 2004. PMID: 15615521

3

Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model.

Handratta VD, Vasaitis TS, Njar VC, Gediya LK, Kataria R, Chopra P, Newman D Jr, Farquhar R, Guo Z, Qiu Y, Brodie AM. Handratta VD, et al. Among authors: njar vc. J Med Chem. 2005 Apr 21;48(8):2972-84. doi: 10.1021/jm040202w. J Med Chem. 2005. PMID: 15828836

4

A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.

Gediya LK, Chopra P, Purushottamachar P, Maheshwari N, Njar VC. Gediya LK, et al. Among authors: njar vc. J Med Chem. 2005 Jul 28;48(15):5047-51. doi: 10.1021/jm058214k. J Med Chem. 2005. PMID: 16033284

5

Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases.

Njar VC, Gediya L, Purushottamachar P, Chopra P, Vasaitis TS, Khandelwal A, Mehta J, Huynh C, Belosay A, Patel J. Njar VC, et al. Bioorg Med Chem. 2006 Jul 1;14(13):4323-40. doi: 10.1016/j.bmc.2006.02.041. Epub 2006 Mar 10. Bioorg Med Chem. 2006. PMID: 16530416 Review.

6

Retinoids in clinical use.

Njar VC, Gediya L, Purushottamachar P, Chopra P, Belosay A, Patel JB. Njar VC, et al. Med Chem. 2006 Jul;2(4):431-8. doi: 10.2174/157340606777724022. Med Chem. 2006. PMID: 16848757 Review.

7

First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents.

Purushottamachar P, Khandelwal A, Chopra P, Maheshwari N, Gediya LK, Vasaitis TS, Bruno RD, Clement OO, Njar VC. Purushottamachar P, et al. Among authors: njar vc. Bioorg Med Chem. 2007 May 15;15(10):3413-21. doi: 10.1016/j.bmc.2007.03.019. Epub 2007 Mar 13. Bioorg Med Chem. 2007. PMID: 17383188 Free PMC article.

8

Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth.

Patel JB, Mehta J, Belosay A, Sabnis G, Khandelwal A, Brodie AM, Soprano DR, Njar VC. Patel JB, et al. Among authors: njar vc. Br J Cancer. 2007 Apr 23;96(8):1204-15. doi: 10.1038/sj.bjc.6603705. Epub 2007 Mar 27. Br J Cancer. 2007. PMID: 17387344 Free PMC article.

9

Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at alpha7* nicotinic receptors.

Lopes C, Pereira EF, Wu HQ, Purushottamachar P, Njar V, Schwarcz R, Albuquerque EX. Lopes C, et al. J Pharmacol Exp Ther. 2007 Jul;322(1):48-58. doi: 10.1124/jpet.107.123109. Epub 2007 Apr 19. J Pharmacol Exp Ther. 2007. PMID: 17446300

10

Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.

Gediya LK, Belosay A, Khandelwal A, Purushottamachar P, Njar VC. Gediya LK, et al. Among authors: njar vc. Bioorg Med Chem. 2008 Mar 15;16(6):3352-60. doi: 10.1016/j.bmc.2007.12.007. Epub 2007 Dec 8. Bioorg Med Chem. 2008. PMID: 18166465 Free PMC article.

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