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Efficient In Vitro and In Vivo Activity of Glyco-Engineered Plant-Produced Rabies Monoclonal Antibodies E559 and 62-71-3.
Tsekoa TL, Lotter-Stark T, Buthelezi S, Chakauya E, Stoychev SH, Sabeta C, Shumba W, Phahladira B, Hume S, Morton J, Rupprecht CE, Steinkellner H, Pauly M, Zeitlin L, Whaley K, Chikwamba R. Tsekoa TL, et al. Among authors: morton j. PLoS One. 2016 Jul 18;11(7):e0159313. doi: 10.1371/journal.pone.0159313. eCollection 2016. PLoS One. 2016. PMID: 27427976 Free PMC article.
Emerging antibody-based products.
Whaley KJ, Morton J, Hume S, Hiatt E, Bratcher B, Klimyuk V, Hiatt A, Pauly M, Zeitlin L. Whaley KJ, et al. Among authors: morton j. Curr Top Microbiol Immunol. 2014;375:107-26. doi: 10.1007/82_2012_240. Curr Top Microbiol Immunol. 2014. PMID: 22772797 Review.
Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques.
Olinger GG Jr, Pettitt J, Kim D, Working C, Bohorov O, Bratcher B, Hiatt E, Hume SD, Johnson AK, Morton J, Pauly M, Whaley KJ, Lear CM, Biggins JE, Scully C, Hensley L, Zeitlin L. Olinger GG Jr, et al. Among authors: morton j. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):18030-5. doi: 10.1073/pnas.1213709109. Epub 2012 Oct 15. Proc Natl Acad Sci U S A. 2012. PMID: 23071322 Free PMC article.
Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail.
Pettitt J, Zeitlin L, Kim DH, Working C, Johnson JC, Bohorov O, Bratcher B, Hiatt E, Hume SD, Johnson AK, Morton J, Pauly MH, Whaley KJ, Ingram MF, Zovanyi A, Heinrich M, Piper A, Zelko J, Olinger GG. Pettitt J, et al. Among authors: morton j. Sci Transl Med. 2013 Aug 21;5(199):199ra113. doi: 10.1126/scitranslmed.3006608. Sci Transl Med. 2013. PMID: 23966302
Chimeric plantibody passively protects mice against aerosolized ricin challenge.
Sully EK, Whaley KJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Pauly MH, Velasco J, Hiatt E, Morton J, Swope K, Roy CJ, Zeitlin L, Mantis NJ. Sully EK, et al. Among authors: morton j. Clin Vaccine Immunol. 2014 May;21(5):777-82. doi: 10.1128/CVI.00003-14. Epub 2014 Feb 26. Clin Vaccine Immunol. 2014. PMID: 24574537 Free PMC article.
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp.
Qiu X, Wong G, Audet J, Bello A, Fernando L, Alimonti JB, Fausther-Bovendo H, Wei H, Aviles J, Hiatt E, Johnson A, Morton J, Swope K, Bohorov O, Bohorova N, Goodman C, Kim D, Pauly MH, Velasco J, Pettitt J, Olinger GG, Whaley K, Xu B, Strong JE, Zeitlin L, Kobinger GP. Qiu X, et al. Among authors: morton j. Nature. 2014 Oct 2;514(7520):47-53. doi: 10.1038/nature13777. Epub 2014 Aug 29. Nature. 2014. PMID: 25171469 Free PMC article.
Hexavalent sperm-binding IgG antibody released from vaginal film for development of potent on-demand nonhormonal female contraception.
Shrestha B, Vincent K, Schaefer A, Zhu Y, Vargas G, Motamedi M, Swope K, Morton J, Simpson C, Pham H, Brennan MB, Pauly MH, Zeitlin L, Bratcher B, Whaley KJ, Moench TR, Lai SK. Shrestha B, et al. Among authors: morton j. Proc Natl Acad Sci U S A. 2021 Nov 30;118(48):e2107832118. doi: 10.1073/pnas.2107832118. Proc Natl Acad Sci U S A. 2021. PMID: 34815336 Free PMC article.
Reproducibility and flexibility of monoclonal antibody production with Nicotiana benthamiana.
Swope K, Morton J, Pogue GP, Burden L, Partain N, Hume S, Shepherd J, Simpson CA, Brennan MB, Furman TC, Kingrey-Gebe S, Martinez T, McDonough J, Pauly MH, Whaley KJ, Zeitlin L, Bratcher B, Haydon H. Swope K, et al. Among authors: morton j. MAbs. 2022 Jan-Dec;14(1):2013594. doi: 10.1080/19420862.2021.2013594. MAbs. 2022. PMID: 35000569 Free PMC article.
ZB-06, a vaginal film containing an engineered human contraceptive antibody (HC4-N), demonstrates safety and efficacy in a phase 1 postcoital test and safety study.
Thurman AR, Moench TR, Hoke M, Politch JA, Cabral H, Mausser E, Nador E, Morton J, Hamorsky K, Swope K, Bratcher B, Anderson DJ, Whaley KJ. Thurman AR, et al. Among authors: morton j. Am J Obstet Gynecol. 2023 Jun;228(6):716.e1-716.e12. doi: 10.1016/j.ajog.2023.02.024. Epub 2023 Mar 2. Am J Obstet Gynecol. 2023. PMID: 36870409 Free article. Clinical Trial.
2,888 results