Abstract
Recent incidents in the United States and abroad have heightened concerns about the use of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for the ability to passively protect mice from a lethal-dose ricin challenge. The most effective antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by injection and inhalation.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antibodies, Monoclonal / administration & dosage
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Antibodies, Neutralizing / administration & dosage
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Antitoxins / administration & dosage*
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Female
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Immunization, Passive / methods*
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Mice, Inbred BALB C
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Plantibodies / administration & dosage*
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Poisoning / prevention & control*
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Ricin / antagonists & inhibitors*
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Ricin / toxicity*
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Survival Analysis
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Treatment Outcome
Substances
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Antibodies, Monoclonal
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Antibodies, Neutralizing
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Antitoxins
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Plantibodies
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Ricin