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Identification of Inhibitors to Trypanosoma cruzi Sirtuins Based on Compounds Developed to Human Enzymes.
Matutino Bastos T, Botelho Pereira Soares M, Haddad Franco C, Alcântara L, Antonini L, Sabatino M, Mautone N, Holanda Freitas-Junior L, Moraes CB, Ragno R, Rotili D, Schenkman S, Mai A, Silvio Moretti N. Matutino Bastos T, et al. Among authors: moraes cb. Int J Mol Sci. 2020 May 22;21(10):3659. doi: 10.3390/ijms21103659. Int J Mol Sci. 2020. PMID: 32455951 Free PMC article.
Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity.
Zingales B, Miles MA, Moraes CB, Luquetti A, Guhl F, Schijman AG, Ribeiro I; Drugs for Neglected Disease Initiative; Chagas Clinical Research Platform Meeting. Zingales B, et al. Among authors: moraes cb. Mem Inst Oswaldo Cruz. 2014 Sep;109(6):828-33. doi: 10.1590/0074-0276140156. Epub 2014 Aug 22. Mem Inst Oswaldo Cruz. 2014. PMID: 25317712 Free PMC article.
Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.
Di Pisa F, Landi G, Dello Iacono L, Pozzi C, Borsari C, Ferrari S, Santucci M, Santarem N, Cordeiro-da-Silva A, Moraes CB, Alcantara LM, Fontana V, Freitas-Junior LH, Gul S, Kuzikov M, Behrens B, Pöhner I, Wade RC, Costi MP, Mangani S. Di Pisa F, et al. Among authors: moraes cb. Molecules. 2017 Mar 8;22(3):426. doi: 10.3390/molecules22030426. Molecules. 2017. PMID: 28282886 Free PMC article.
Investigating the structure-activity relationships of N'-[(5-nitrofuran-2-yl) methylene] substituted hydrazides against Trypanosoma cruzi to design novel active compounds.
Palace-Berl F, Pasqualoto KFM, Zingales B, Moraes CB, Bury M, Franco CH, da Silva Neto AL, Murayama JS, Nunes SL, Silva MN, Tavares LC. Palace-Berl F, et al. Among authors: moraes cb. Eur J Med Chem. 2018 Jan 20;144:29-40. doi: 10.1016/j.ejmech.2017.12.011. Epub 2017 Dec 5. Eur J Med Chem. 2018. PMID: 29247858
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.
Linciano P, Moraes CB, Alcantara LM, Franco CH, Pascoalino B, Freitas-Junior LH, Macedo S, Santarem N, Cordeiro-da-Silva A, Gul S, Witt G, Kuzikov M, Ellinger B, Ferrari S, Luciani R, Quotadamo A, Costantino L, Costi MP. Linciano P, et al. Among authors: moraes cb. Eur J Med Chem. 2018 Feb 25;146:423-434. doi: 10.1016/j.ejmech.2018.01.043. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29407968
61 results