Mishra SJ - Search Results

1

Selective Inhibition of the Hsp90α Isoform.

Mishra SJ, Khandelwal A, Banerjee M, Balch M, Peng S, Davis RE, Merfeld T, Munthali V, Deng J, Matts RL, Blagg BSJ. Mishra SJ, et al. Angew Chem Int Ed Engl. 2021 May 3;60(19):10547-10551. doi: 10.1002/anie.202015422. Epub 2021 Mar 26. Angew Chem Int Ed Engl. 2021. PMID: 33621416 Free PMC article.

2

Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma.

Stothert AR, Suntharalingam A, Huard DJ, Fontaine SN, Crowley VM, Mishra S, Blagg BS, Lieberman RL, Dickey CA. Stothert AR, et al. Hum Mol Genet. 2014 Dec 15;23(24):6470-80. doi: 10.1093/hmg/ddu367. Epub 2014 Jul 15. Hum Mol Genet. 2014. PMID: 25027323 Free PMC article.

3

Development of radamide analogs as Grp94 inhibitors.

Muth A, Crowley V, Khandelwal A, Mishra S, Zhao J, Hall J, Blagg BS. Muth A, et al. Bioorg Med Chem. 2014 Aug 1;22(15):4083-98. doi: 10.1016/j.bmc.2014.05.075. Epub 2014 Jun 12. Bioorg Med Chem. 2014. PMID: 25027801 Free PMC article.

4

Development of Glucose Regulated Protein 94-Selective Inhibitors Based on the BnIm and Radamide Scaffold.

Crowley VM, Khandelwal A, Mishra S, Stothert AR, Huard DJ, Zhao J, Muth A, Duerfeldt AS, Kizziah JL, Lieberman RL, Dickey CA, Blagg BS. Crowley VM, et al. J Med Chem. 2016 Apr 14;59(7):3471-88. doi: 10.1021/acs.jmedchem.6b00085. Epub 2016 Apr 4. J Med Chem. 2016. PMID: 27003516 Free PMC article.

5

Transformation of the Non-Selective Aminocyclohexanol-Based Hsp90 Inhibitor into a Grp94-Seletive Scaffold.

Mishra SJ, Ghosh S, Stothert AR, Dickey CA, Blagg BS. Mishra SJ, et al. ACS Chem Biol. 2017 Jan 20;12(1):244-253. doi: 10.1021/acschembio.6b00747. Epub 2016 Dec 13. ACS Chem Biol. 2017. PMID: 27959508 Free PMC article.

6

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.

Stothert AR, Suntharalingam A, Tang X, Crowley VM, Mishra SJ, Webster JM, Nordhues BA, Huard DJE, Passaglia CL, Lieberman RL, Blagg BSJ, Blair LJ, Koren J 3rd, Dickey CA. Stothert AR, et al. Among authors: mishra sj. Sci Rep. 2017 Dec 20;7(1):17951. doi: 10.1038/s41598-017-18344-4. Sci Rep. 2017. PMID: 29263415 Free PMC article.

7

Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor.

Khandelwal A, Kent CN, Balch M, Peng S, Mishra SJ, Deng J, Day VW, Liu W, Subramanian C, Cohen M, Holzbeierlein JM, Matts R, Blagg BSJ. Khandelwal A, et al. Among authors: mishra sj. Nat Commun. 2018 Jan 30;9(1):425. doi: 10.1038/s41467-017-02013-1. Nat Commun. 2018. PMID: 29382832 Free PMC article.

8

The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain.

Lei W, Duron DI, Stine C, Mishra S, Blagg BSJ, Streicher JM. Lei W, et al. Front Mol Neurosci. 2019 Nov 29;12:294. doi: 10.3389/fnmol.2019.00294. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31849607 Free PMC article.

9

[No title available]

[No authors listed] [No authors listed] PMID: 32301839

10

Inhibition of Hsp90 in the spinal cord enhances the antinociceptive effects of morphine by activating an ERK-RSK pathway.

Duron DI, Lei W, Barker NK, Stine C, Mishra S, Blagg BSJ, Langlais PR, Streicher JM. Duron DI, et al. Sci Signal. 2020 May 5;13(630):eaaz1854. doi: 10.1126/scisignal.aaz1854. Sci Signal. 2020. PMID: 32371496 Free PMC article.

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