Restoration of glycoprotein Erns dimerization via pseudoreversion partially restores virulence of classical swine fever virus.
Tucakov AK, Yavuz S, Schürmann EM, Mischler M, Klingebeil A, Meyers G.
Tucakov AK, et al. Among authors: meyers g.
J Gen Virol. 2018 Jan;99(1):86-96. doi: 10.1099/jgv.0.000990. Epub 2017 Dec 13.
J Gen Virol. 2018.
PMID: 29235980
Mutant CSFV lacking cysteine (Cys) 171, the residue responsible for intermolecular disulfide bond formation, were found to be attenuated in pigs (Tews BA, Schurmann EM, Meyers G. J Virol 2009;83:4823-4834). In the course of an animal experiment with such a dimerizat …
Mutant CSFV lacking cysteine (Cys) 171, the residue responsible for intermolecular disulfide bond formation, were found to be attenuated in …