Metz A - Search Results

1

Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization.

Schanda J, Lee CW, Wohlan K, Müller-Kuller U, Kunkel H, Coco IQ, Stein S, Metz A, Koch J, Lausen J, Platzbecker U, Medyouf H, Gohlke H, Heuser M, Eder M, Grez M, Scherr M, Wichmann C. Schanda J, et al. Among authors: metz a. Haematologica. 2017 May;102(5):e170-e174. doi: 10.3324/haematol.2016.161570. Epub 2017 Feb 2. Haematologica. 2017. PMID: 28154087 Free PMC article. No abstract available.

2

From determinants of RUNX1/ETO tetramerization to small-molecule protein-protein interaction inhibitors targeting acute myeloid leukemia.

Metz A, Schanda J, Grez M, Wichmann C, Gohlke H. Metz A, et al. J Chem Inf Model. 2013 Sep 23;53(9):2197-202. doi: 10.1021/ci400332e. Epub 2013 Sep 12. J Chem Inf Model. 2013. PMID: 23957251

3

Modulating protein-protein interactions: from structural determinants of binding to druggability prediction to application.

Metz A, Ciglia E, Gohlke H. Metz A, et al. Curr Pharm Des. 2012;18(30):4630-47. doi: 10.2174/138161212802651553. Curr Pharm Des. 2012. PMID: 22650257 Review.

4

Hot spots and transient pockets: predicting the determinants of small-molecule binding to a protein-protein interface.

Metz A, Pfleger C, Kopitz H, Pfeiffer-Marek S, Baringhaus KH, Gohlke H. Metz A, et al. J Chem Inf Model. 2012 Jan 23;52(1):120-33. doi: 10.1021/ci200322s. Epub 2011 Dec 27. J Chem Inf Model. 2012. PMID: 22087639

5

Redesigning Aldolase Stereoselectivity by Homologous Grafting.

Bisterfeld C, Classen T, Küberl I, Henßen B, Metz A, Gohlke H, Pietruszka J. Bisterfeld C, et al. Among authors: metz a. PLoS One. 2016 Jun 21;11(6):e0156525. doi: 10.1371/journal.pone.0156525. eCollection 2016. PLoS One. 2016. PMID: 27327271 Free PMC article.

6

Targeting a Cryptic Pocket in a Protein-Protein Contact by Disulfide-Induced Rupture of a Homodimeric Interface.

Nguyen D, Xie X, Jakobi S, Terwesten F, Metz A, Nguyen TXP, Palchykov VA, Heine A, Reuter K, Klebe G. Nguyen D, et al. Among authors: metz a. ACS Chem Biol. 2021 Jun 18;16(6):1090-1098. doi: 10.1021/acschembio.1c00296. Epub 2021 Jun 3. ACS Chem Biol. 2021. PMID: 34081441

7

Experimental Active-Site Mapping by Fragments: Hot Spots Remote from the Catalytic Center of Endothiapepsin.

Radeva N, Krimmer SG, Stieler M, Fu K, Wang X, Ehrmann FR, Metz A, Huschmann FU, Weiss MS, Mueller U, Schiebel J, Heine A, Klebe G. Radeva N, et al. Among authors: metz a. J Med Chem. 2016 Aug 25;59(16):7561-75. doi: 10.1021/acs.jmedchem.6b00645. Epub 2016 Aug 12. J Med Chem. 2016. PMID: 27463859

8

Hot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzyme.

Jakobi S, Nguyen TX, Debaene F, Metz A, Sanglier-Cianférani S, Reuter K, Klebe G. Jakobi S, et al. Among authors: metz a. Proteins. 2014 Oct;82(10):2713-32. doi: 10.1002/prot.24637. Epub 2014 Jul 14. Proteins. 2014. PMID: 24975703

9

One Question, Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists.

Schiebel J, Radeva N, Köster H, Metz A, Krotzky T, Kuhnert M, Diederich WE, Heine A, Neumann L, Atmanene C, Roecklin D, Vivat-Hannah V, Renaud JP, Meinecke R, Schlinck N, Sitte A, Popp F, Zeeb M, Klebe G. Schiebel J, et al. Among authors: metz a. ChemMedChem. 2015 Sep;10(9):1511-21. doi: 10.1002/cmdc.201500267. Epub 2015 Aug 10. ChemMedChem. 2015. PMID: 26259992

10

F2X-Universal and F2X-Entry: Structurally Diverse Compound Libraries for Crystallographic Fragment Screening.

Wollenhaupt J, Metz A, Barthel T, Lima GMA, Heine A, Mueller U, Klebe G, Weiss MS. Wollenhaupt J, et al. Among authors: metz a. Structure. 2020 Jun 2;28(6):694-706.e5. doi: 10.1016/j.str.2020.04.019. Epub 2020 May 14. Structure. 2020. PMID: 32413289 Free article.

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