Suppression of RUNX1/ETO oncogenic activity by a small molecule inhibitor of tetramerization

Haematologica. 2017 May;102(5):e170-e174. doi: 10.3324/haematol.2016.161570. Epub 2017 Feb 2.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Core Binding Factor Alpha 2 Subunit / antagonists & inhibitors*
  • Core Binding Factor Alpha 2 Subunit / genetics
  • Disease Models, Animal
  • Gene Expression
  • Humans
  • Mice
  • Oncogene Proteins, Fusion / antagonists & inhibitors*
  • Oncogene Proteins, Fusion / chemistry
  • Oncogene Proteins, Fusion / genetics
  • Oncogene Proteins, Fusion / metabolism
  • Protein Multimerization / drug effects*
  • RUNX1 Translocation Partner 1 Protein / antagonists & inhibitors*
  • RUNX1 Translocation Partner 1 Protein / genetics
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Core Binding Factor Alpha 2 Subunit
  • Oncogene Proteins, Fusion
  • RUNX1 Translocation Partner 1 Protein
  • RUNX1 protein, human
  • RUNX1T1 protein, human