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Page 1
Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin.
Liu N, Konuma T, Sharma R, Wang D, Zhao N, Cao L, Ju Y, Liu D, Wang S, Bosch A, Sun Y, Zhang S, Ji D, Nagatoishi S, Suzuki N, Kikuchi M, Wakamori M, Zhao C, Ren C, Zhou TJ, Xu Y, Meslamani J, Fu S, Umehara T, Tsumoto K, Akashi S, Zeng L, Roeder RG, Walsh MJ, Zhang Q, Zhou MM. Liu N, et al. Among authors: meslamani j. Mol Cell. 2023 Jul 6;83(13):2206-2221.e11. doi: 10.1016/j.molcel.2023.05.022. Epub 2023 Jun 12. Mol Cell. 2023. PMID: 37311463 Free article.
HIPK2 directs cell type-specific regulation of STAT3 transcriptional activity in Th17 cell differentiation.
Cheung KL, Jaganathan A, Hu Y, Xu F, Lejeune A, Sharma R, Caescu CI, Meslamani J, Vincek A, Zhang F, Lee K, Zaware N, Qayum AA, Ren C, Kaplan MH, He JC, Xiong H, Zhou MM. Cheung KL, et al. Among authors: meslamani j. Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2117112119. doi: 10.1073/pnas.2117112119. Epub 2022 Mar 28. Proc Natl Acad Sci U S A. 2022. PMID: 35344430 Free PMC article.
Correction to: BRADSHAW: a system for automated molecular design.
Green DVS, Pickett S, Luscombe C, Senger S, Marcus D, Meslamani J, Brett D, Powell A, Masson J. Green DVS, et al. Among authors: meslamani j. J Comput Aided Mol Des. 2020 Jul;34(7):767. doi: 10.1007/s10822-019-00243-7. J Comput Aided Mol Des. 2020. PMID: 31691917 Free PMC article.
BRADSHAW: a system for automated molecular design.
Green DVS, Pickett S, Luscombe C, Senger S, Marcus D, Meslamani J, Brett D, Powell A, Masson J. Green DVS, et al. Among authors: meslamani j. J Comput Aided Mol Des. 2020 Jul;34(7):747-765. doi: 10.1007/s10822-019-00234-8. Epub 2019 Oct 21. J Comput Aided Mol Des. 2020. PMID: 31637565 Free PMC article.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
Harris PA, Faucher N, George N, Eidam PM, King BW, White GV, Anderson NA, Bandyopadhyay D, Beal AM, Beneton V, Berger SB, Campobasso N, Campos S, Capriotti CA, Cox JA, Daugan A, Donche F, Fouchet MH, Finger JN, Geddes B, Gough PJ, Grondin P, Hoffman BL, Hoffman SJ, Hutchinson SE, Jeong JU, Jigorel E, Lamoureux P, Leister LK, Lich JD, Mahajan MK, Meslamani J, Mosley JE, Nagilla R, Nassau PM, Ng SL, Ouellette MT, Pasikanti KK, Potvain F, Reilly MA, Rivera EJ, Sautet S, Schaeffer MC, Sehon CA, Sun H, Thorpe JH, Totoritis RD, Ward P, Wellaway N, Wisnoski DD, Woolven JM, Bertin J, Marquis RW. Harris PA, et al. Among authors: meslamani j. J Med Chem. 2019 May 23;62(10):5096-5110. doi: 10.1021/acs.jmedchem.9b00318. Epub 2019 May 2. J Med Chem. 2019. PMID: 31013427
Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth.
Ren C, Zhang G, Han F, Fu S, Cao Y, Zhang F, Zhang Q, Meslamani J, Xu Y, Ji D, Cao L, Zhou Q, Cheung KL, Sharma R, Babault N, Yi Z, Zhang W, Walsh MJ, Zeng L, Zhou MM. Ren C, et al. Among authors: meslamani j. Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):7949-7954. doi: 10.1073/pnas.1720000115. Epub 2018 Jul 16. Proc Natl Acad Sci U S A. 2018. PMID: 30012592 Free PMC article.
BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Cheung K, Lu G, Sharma R, Vincek A, Zhang R, Plotnikov AN, Zhang F, Zhang Q, Ju Y, Hu Y, Zhao L, Han X, Meslamani J, Xu F, Jaganathan A, Shen T, Zhu H, Rusinova E, Zeng L, Zhou J, Yang J, Peng L, Ohlmeyer M, Walsh MJ, Zhang DY, Xiong H, Zhou MM. Cheung K, et al. Among authors: meslamani j. Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):2952-2957. doi: 10.1073/pnas.1615601114. Epub 2017 Mar 6. Proc Natl Acad Sci U S A. 2017. PMID: 28265070 Free PMC article.
Structural features and inhibitors of bromodomains.
Meslamani J, Smith SG, Sanchez R, Zhou MM. Meslamani J, et al. Drug Discov Today Technol. 2016 Mar;19:3-15. doi: 10.1016/j.ddtec.2016.09.001. Epub 2016 Sep 22. Drug Discov Today Technol. 2016. PMID: 27769355 Free PMC article. Review.
The bromodomain: from epigenome reader to druggable target.
Sanchez R, Meslamani J, Zhou MM. Sanchez R, et al. Among authors: meslamani j. Biochim Biophys Acta. 2014 Aug;1839(8):676-85. doi: 10.1016/j.bbagrm.2014.03.011. Epub 2014 Mar 28. Biochim Biophys Acta. 2014. PMID: 24686119 Free PMC article. Review.
16 results