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Characterization of the pathoimmunology of necrotizing enterocolitis reveals novel therapeutic opportunities.
Cho SX, Rudloff I, Lao JC, Pang MA, Goldberg R, Bui CB, McLean CA, Stock M, Klassert TE, Slevogt H, Mangan NE, Cheng W, Fischer D, Gfroerer S, Sandhu MK, Ngo D, Bujotzek A, Lariviere L, Schumacher F, Tiefenthaler G, Beker F, Collins C, Kamlin COF, König K, Malhotra A, Tan K, Theda C, Veldman A, Ellisdon AM, Whisstock JC, Berger PJ, Nold-Petry CA, Nold MF. Cho SX, et al. Among authors: mclean ca. Nat Commun. 2020 Nov 13;11(1):5794. doi: 10.1038/s41467-020-19400-w. Nat Commun. 2020. PMID: 33188181 Free PMC article.
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer.
Rodgers SJ, Ooms LM, Oorschot VMJ, Schittenhelm RB, Nguyen EV, Hamila SA, Rynkiewicz N, Gurung R, Eramo MJ, Sriratana A, Fedele CG, Caramia F, Loi S, Kerr G, Abud HE, Ramm G, Papa A, Ellisdon AM, Daly RJ, McLean CA, Mitchell CA. Rodgers SJ, et al. Among authors: mclean ca. Nat Commun. 2021 May 25;12(1):3140. doi: 10.1038/s41467-021-23241-6. Nat Commun. 2021. PMID: 34035258 Free PMC article.
Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants.
Lao JC, Bui CB, Pang MA, Cho SX, Rudloff I, Elgass K, Schröder J, Maksimenko A, Mangan NE, Starkey MR, Skuza EM, Sun YBY, Beker F, Collins CL, Kamlin OF, König K, Malhotra A, Tan K, Theda C, Young MJ, McLean CA, Wilson NJ, Sehgal A, Hansbro PM, Pearson JT, Polo JM, Veldman A, Berger PJ, Nold-Petry CA, Nold MF. Lao JC, et al. Among authors: mclean ca. Sci Transl Med. 2022 Apr 6;14(639):eaaz8454. doi: 10.1126/scitranslmed.aaz8454. Epub 2022 Apr 6. Sci Transl Med. 2022. PMID: 35385341
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.
Hildebrand JM, Kauppi M, Majewski IJ, Liu Z, Cox AJ, Miyake S, Petrie EJ, Silk MA, Li Z, Tanzer MC, Brumatti G, Young SN, Hall C, Garnish SE, Corbin J, Stutz MD, Di Rago L, Gangatirkar P, Josefsson EC, Rigbye K, Anderton H, Rickard JA, Tripaydonis A, Sheridan J, Scerri TS, Jackson VE, Czabotar PE, Zhang JG, Varghese L, Allison CC, Pellegrini M, Tannahill GM, Hatchell EC, Willson TA, Stockwell D, de Graaf CA, Collinge J, Hilton A, Silke N, Spall SK, Chau D, Athanasopoulos V, Metcalf D, Laxer RM, Bassuk AG, Darbro BW, Fiatarone Singh MA, Vlahovich N, Hughes D, Kozlovskaia M, Ascher DB, Warnatz K, Venhoff N, Thiel J, Biben C, Blum S, Reveille J, Hildebrand MS, Vinuesa CG, McCombe P, Brown MA, Kile BT, McLean C, Bahlo M, Masters SL, Nakano H, Ferguson PJ, Murphy JM, Alexander WS, Silke J. Hildebrand JM, et al. Among authors: mclean c. Nat Commun. 2020 Jun 19;11(1):3150. doi: 10.1038/s41467-020-16819-z. Nat Commun. 2020. PMID: 32561755 Free PMC article.
Transcriptional signature in microglia associated with Aβ plaque phagocytosis.
Grubman A, Choo XY, Chew G, Ouyang JF, Sun G, Croft NP, Rossello FJ, Simmons R, Buckberry S, Landin DV, Pflueger J, Vandekolk TH, Abay Z, Zhou Y, Liu X, Chen J, Larcombe M, Haynes JM, McLean C, Williams S, Chai SY, Wilson T, Lister R, Pouton CW, Purcell AW, Rackham OJL, Petretto E, Polo JM. Grubman A, et al. Nat Commun. 2021 May 21;12(1):3015. doi: 10.1038/s41467-021-23111-1. Nat Commun. 2021. PMID: 34021136 Free PMC article.
297 results