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mRNA structure regulates protein expression through changes in functional half-life.
Mauger DM, Cabral BJ, Presnyak V, Su SV, Reid DW, Goodman B, Link K, Khatwani N, Reynders J, Moore MJ, McFadyen IJ. Mauger DM, et al. Among authors: mcfadyen ij. Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24075-24083. doi: 10.1073/pnas.1908052116. Epub 2019 Nov 11. Proc Natl Acad Sci U S A. 2019. PMID: 31712433 Free PMC article.
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines.
Hassett KJ, Benenato KE, Jacquinet E, Lee A, Woods A, Yuzhakov O, Himansu S, Deterling J, Geilich BM, Ketova T, Mihai C, Lynn A, McFadyen I, Moore MJ, Senn JJ, Stanton MG, Almarsson Ö, Ciaramella G, Brito LA. Hassett KJ, et al. Mol Ther Nucleic Acids. 2019 Apr 15;15:1-11. doi: 10.1016/j.omtn.2019.01.013. Epub 2019 Feb 7. Mol Ther Nucleic Acids. 2019. PMID: 30785039 Free PMC article.
Towards ambient temperature-stable vaccines: the identification of thermally stabilizing liquid formulations for measles virus using an innovative high-throughput infectivity assay.
Schlehuber LD, McFadyen IJ, Shu Y, Carignan J, Duprex WP, Forsyth WR, Ho JH, Kitsos CM, Lee GY, Levinson DA, Lucier SC, Moore CB, Nguyen NT, Ramos J, Weinstock BA, Zhang J, Monagle JA, Gardner CR, Alvarez JC. Schlehuber LD, et al. Among authors: mcfadyen ij. Vaccine. 2011 Jul 12;29(31):5031-9. doi: 10.1016/j.vaccine.2011.04.079. Epub 2011 May 25. Vaccine. 2011. PMID: 21616113 Free article.
Use of structure-based drug design approaches to obtain novel anthranilic acid acyl carrier protein synthase inhibitors.
Joseph-McCarthy D, Parris K, Huang A, Failli A, Quagliato D, Dushin EG, Novikova E, Severina E, Tuckman M, Petersen PJ, Dean C, Fritz CC, Meshulam T, DeCenzo M, Dick L, McFadyen IJ, Somers WS, Lovering F, Gilbert AM. Joseph-McCarthy D, et al. Among authors: mcfadyen ij. J Med Chem. 2005 Dec 15;48(25):7960-9. doi: 10.1021/jm050523n. J Med Chem. 2005. PMID: 16335920
30 results