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Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Merfeld T, Peng S, Keegan BM, Crowley VM, Brackett CM, Gutierrez A, McCann NR, Reynolds TS, Rhodes MC, Byrd KM, Deng J, Matts RL, Blagg BSJ. Merfeld T, et al. Among authors: matts rl. Eur J Med Chem. 2023 Oct 5;258:115531. doi: 10.1016/j.ejmech.2023.115531. Epub 2023 Jun 5. Eur J Med Chem. 2023. PMID: 37307624
Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor.
Khandelwal A, Kent CN, Balch M, Peng S, Mishra SJ, Deng J, Day VW, Liu W, Subramanian C, Cohen M, Holzbeierlein JM, Matts R, Blagg BSJ. Khandelwal A, et al. Nat Commun. 2018 Jan 30;9(1):425. doi: 10.1038/s41467-017-02013-1. Nat Commun. 2018. PMID: 29382832 Free PMC article.
Selective Inhibition of the Hsp90α Isoform.
Mishra SJ, Khandelwal A, Banerjee M, Balch M, Peng S, Davis RE, Merfeld T, Munthali V, Deng J, Matts RL, Blagg BSJ. Mishra SJ, et al. Among authors: matts rl. Angew Chem Int Ed Engl. 2021 May 3;60(19):10547-10551. doi: 10.1002/anie.202015422. Epub 2021 Mar 26. Angew Chem Int Ed Engl. 2021. PMID: 33621416 Free PMC article.
A systematic protocol for the characterization of Hsp90 modulators.
Matts RL, Brandt GE, Lu Y, Dixit A, Mollapour M, Wang S, Donnelly AC, Neckers L, Verkhivker G, Blagg BS. Matts RL, et al. Bioorg Med Chem. 2011 Jan 1;19(1):684-92. doi: 10.1016/j.bmc.2010.10.029. Epub 2010 Oct 19. Bioorg Med Chem. 2011. PMID: 21129982 Free PMC article.
Elucidation of the Hsp90 C-terminal inhibitor binding site.
Matts RL, Dixit A, Peterson LB, Sun L, Voruganti S, Kalyanaraman P, Hartson SD, Verkhivker GM, Blagg BS. Matts RL, et al. ACS Chem Biol. 2011 Aug 19;6(8):800-7. doi: 10.1021/cb200052x. Epub 2011 May 17. ACS Chem Biol. 2011. PMID: 21548602 Free PMC article.
87 results